This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from
Background: APOE epsilon 4 and sex have been linked to increased risk for conversion to Alzheimer's disease (AD). However, the relationship between APOE epsilon 4 gene dose, sex, and AD biomarkers remains understudied.Hobel, ZacharyIsenberg, A. LisetteRaghupathy, DhvaniMack, WendyPa, Judy...
Background & Aim The apolipoprotein E4 (ApoE4) is the most prevalent genetic risk factor for sporadic Alzheimer's disease (AD). More than 50% of AD patients express the ApoE4 protein; which increases the risk of prevalence for AD since it lowers the age of onset by as much as 10-20...
《自然》新闻:This is how an Alzheimer’s gene ravages the brain 链接 《自然》论文: APOE4 impairs myelination via cholesterol dysregulation 发布于 2022-11-30 10:54・IP 属地上海 写下你的评论... 登录知乎,您可以享受以下权益: 更懂你的优质内容 ...
ApoE;fat-free mass;fat mass;Alzheimer’s disease;cross-sectional study;outpatient study 1. Introduction A lower or decreasing body mass is associated with the progression of Alzheimer’s disease (AD) and the risk of mortality in patients with AD [1,2,3,4]. To date, no genetic determinants...
Exploring the role of Amerindian genetic ancestry and ApoEε4 gene on Alzheimer disease in the Peruvian populationThe ApoEε4 allele is a major risk factor for AD whose effect shows strong racial/ethnic differences. Among the populations ApoE shows the strongest effect in East Asians (EA) (ε3...
Alzheimer’s disease. But carrying the APOE4 allele absolutelydoes notmean that cognitive decline or Alzheimer’s disease is definite. Lifestyle choices, which, unlike our genetics, can be modified, play an extremely important role in either enhancing the likelihood of dementia, or providing a mea...
Carriers of this APOE4 “Alzheimer’s gene” variant don’talwaysdevelop the disease — but coming from a deep professional background in biotech, Nelson felt that the more she knows about her Alzheimer’s risk, the better equipped she might be to make lifestyle modifications that can stave ...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat Genet. 2019;51(3):404–13. 4. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of...