Alzheimer's disease (AD) is a progressive neurodegenerative disease, the main pathological hallmark of which is the loss of neurons, resulting in cognitive and memory impairments. Sporadic late-onset AD is the prevalent form of the disease and the apolipoprotein E4 (APOE4) genotype is the ...
APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway p pBackground/p pThe objective of this study was to analyze factors influencing the risk and timing of Alzheimers disease (AD) in central Norway. The itAPO... SB ...
To determine the relationship between apolipoprotein E (APOE)ε4 and sporadic Alzheimer's disease (SAD) in the Mongolian population in China, we examined 106 Mongolian SAD patients in China and 100 Mongolian healthy controls. All subjects were genotyped for APOE. The odds ratio (OR) for developi...
APOE4: THE MOST PREVALENT YET UNDERSTUDIED RISK FACTOR FOR ALZHEIMER'S DISEASE主要由Michaelson Daniel编写,在2016年被《Neurobiology of Aging: Experimental and Clinical Research》收录,原文总共1页。
Background: Apolipoprotein E (ApoE) ε4 genotype is a well-established risk factor for Alzheimer's disease (AD). However, its effect on predicting conversion from normal to "cognitive impairment, no dementia" (CIND) and from CIND to AD i... G Hsiung,A Sadovnick,H Feldman - 《Canadian ...
The modifying effect of rs405509 genotype explained much of the ethnic variability in the AD/ε4 association, and increasing APOE expression might lower AD risk among ε4 homozygotes. Keywords: APOE; promoter polymorphism; Alzheimer’s disease; ethnic variability; brain atrophy; genetic association...
(MCI). We aimed to evaluate the impact of sequential anodal-tDCS on cognitive functions, functional segregation, and integration parameters in patients with MCI, according to high-risk factors for Alzheimer’s disease (AD): amyloid-beta (Aβ) deposition andAPOEε4-allele status. In 32 patients...
Evans1*† Abstract Background: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations ...
Apolipoprotein-E4 (ApoE4) is an important genetic risk factor for Alzheimer’s disease. The development of targeted-replacement human ApoE knock-in mice facilitates research into mechanisms by which ApoE4 affects the brain. We performed meta-analyses and meta-regression analyses to examine differences...
Evans1*† Abstract Background: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations ...