APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...
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但这一基因如何造成大脑损伤一直是一个谜。一项研究现已将APOE4和大脑中错误的胆固醇处理联系起来,这会导致围绕神经纤维、促进电活动的髓鞘缺陷。初步结果显示,这些改变可以导致记忆和学习障碍。这项工作还表明,恢复大脑胆固醇处理的药物可提供治疗。 《自然》新闻:This is how an Alzheimer’s gene ravages the brain...
Exploring the role of Amerindian genetic ancestry and ApoEε4 gene on Alzheimer disease in the Peruvian populationThe ApoEε4 allele is a major risk factor for AD whose effect shows strong racial/ethnic differences. Among the populations ApoE shows the strongest effect in East Asians (EA) (ε3...
One of the hallmarks of the brain of an individual with Alzheimer disease is the accumulation of amyloid-beta peptide (A-beta), something that is believed to be toxic to many brain cells (specifically neurons) and to therefore contribute to the underlyin
APOE基因有2个突变位点,可产生3种等位基因ε2、ε3、ε4,6种基因型ε2/ε2、ε2/ε3、ε2/ε4、ε3/ε3、ε3/ε4、ε4/ε4,分别编码三种载脂蛋白亚型ApoE2、ApoE3和ApoE4,不同亚型在阿尔茨海默病(Alzheimer’s disease,AD)、血脂代谢,以及动脉粥样硬化等心脑血管...
Consequently, these gene expression levels were increased to a lesser extent in ApoE4 TR mouse brains (Figure 6G), suggesting that ApoE4 mice are less competent to consolidate fear memory. We next asked whether the isoform-dependent effect in regulating cholesterol metabolism and histone acetylation...
②Nature:APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia APOE4/4与阿尔茨海默症小胶质细胞损伤性脂滴相关 拓展:这项研究基于单核RNA测序技术,揭示了阿尔茨海默病的遗传风险因素与小胶质细胞脂滴积累和神经毒性小胶质细胞衍生因子之间的联系,可能为阿尔茨海默病提供治疗策略。APOE4(...
Abstract:Objective To explore the anti- inflammatory mechanism of osthole (OST)on in vitro cell model of Alzheimer’s disease through APOE(apolipo protein E,AP0E)-TREM2 (recombinant triggering receptor expressed on myeloid cells 2, TREM2). Methods Mouse microglia (BV2 cells)were divided into ...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...