近日,西班牙圣十字圣保罗医院的科研人员在Nature Medicine发表了题为“APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease”的文章。研究团队分析了美国国家阿尔茨海默病协调中心(NACC)的大型病理数据集,以及迄今为止发表的5个大型多中心队列10,039人的AD生物标志物数据。分析结果发现,APOE4...
近日,来自西班牙巴塞罗那圣十字圣保罗医院的Víctor Montal研究团队在Nature Medicine杂志发表题为APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease的研究论文,该研究利用来自国家阿尔茨海默病协调中心(NACC)的大型病理数据...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating Center a...
The inheritance of Apolipoprotein E4 ( APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports...
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched gene expression in neurodegenerative microglia (MGnD). Here, we show in mice and humans a ne...
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimer’s disease pathology remains poorly understood. Through single-...
Alzheimer's disease(AD)is the most common cause of dementia and presents with an insidious onset and long prodromal period.Despite billions spent on clinical trials and decades of research,there are currently no disease modifying therapies approved for AD.Two of the most well-appreciated risk facto...
The purpose of this mini review is to provide an updated assessment on apolipoprotein E4 status and risk potential of developing dementia and mortality associated with Down syndrome. 展开 关键词: Alzheimer’s disease Apolipoprotein E4 (ApoE4) Beta-amyloid Down syndrome Mortality Neurofibrillary ...
Environmental factors influencing the link between APOE ε4 and Alzheimer's disease (AD) risk While APOE ε4 allele is considered a genetic risk factor for Alzheimer's disease (AD), no relation existed between APOE ε4 and AD in the Yoruba in Nigeria among cohorts included in early prevalence...
Objective: To explore the impact of apoE-4 on Alzheimer9s disease (AD) and its age at onset. Design: A genetic linkage study using affected relative pairs, predominantly siblings. Setting: Three academic medical centers ascertained subjects from memory disorder clinics, nursing homes, and the loca...