This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating Center a...
近日,来自西班牙巴塞罗那圣十字圣保罗医院的Víctor Montal研究团队在Nature Medicine杂志发表题为APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease的研究论文,该研究利用来自国家阿尔茨海默病协调中心(NACC)的大型病理数据...
The inheritance of Apolipoprotein E4 ( APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports...
George Andrew S. Inglis Corresponding author Correspondence to George Andrew S. Inglis. Rights and permissions Reprints and permissions About this article Cite this article Inglis, G.A.S. Exploring how APOEε4 increases Alzheimer’s disease risk in women. Nat Aging 4, 1032 (2024). https://doi...
Alzheimer's disease(AD)is the most common cause of dementia and presents with an insidious onset and long prodromal period.Despite billions spent on clinical trials and decades of research,there are currently no disease modifying therapies approved for AD.Two of the most well-appreciated risk facto...
“Sex,ApoE4 and Alzheimer's disease:rethinking drug discovery in the era of precision medicine”出自《中国神经再生研究(英文版)》期刊2021年第9期文献,主题关键词涉及有等。钛学术提供该文献下载服务。
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative "ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative." Neurology. 1997 Jan;48(1):139-47.Blacker D, Haines JL, Rodes L,... D Blacker,JL Haines,L Rodes,... - 《Neurology》 被引...
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimer’s disease pat
Alzheimer’s disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid
APOE4: The most prevalent yet understudied risk factor for Alzheimer's disease Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant familial AD have been the "lamp posts" under which the AD field has bee... Daniel M. Michaelson - 《Alzheimers & Dementia》 被...