This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from
Background & Aim The apolipoprotein E4 (ApoE4) is the most prevalent genetic risk factor for sporadic Alzheimer's disease (AD). More than 50% of AD patients express the ApoE4 protein; which increases the risk of prevalence for AD since it lowers the age of onset by as much as 10-20...
《自然》新闻:This is how an Alzheimer’s gene ravages the brain 链接 《自然》论文: APOE4 impairs myelination via cholesterol dysregulation 发布于 2022-11-30 10:54・IP 属地上海 写下你的评论... 登录知乎,您可以享受以下权益: 更懂你的优质内容 ...
There are dozens of genes that have been linked to increased Alzheimer’s risk. Some of these genes have just a tiny bit of influence over a person’s likelihood of developing Alzheimer’s; others have quite a lot. One particular gene variant, called APOE4, has accrued a reputation as “...
The results were quite remarkable. Children and adolescents who carried the APOE4 allele, the so-called “Alzheimer’s gene,” showed measurably lower scores on verbal, performance and full-scale IQ assessments in comparison to those not positive for this genetic marker. ...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
The loci identified are located in trans as well as cis to APOE and implicate genes involved in lipid homeostasis. Keywords: Alzheimer's disease, APOE, Apolipoprotein E, DNA methylation, Cholesterol, Lipids Background The ε4 allele of the apolipoprotein E gene (APOE) is the strongest genetic ...
APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...
BACKGROUND: One of the characteristic features of Alzheimer's disease (AD) is the degeneration of the cholinergic system. The gene encoding choline acetyltransferase (ChAT), a key enzyme in cholinergic function, is a candidate gene conferring risk for AD. But the genetic association of the enzyme...
The −491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEϵ4 allele and Alzheimer's Disease Several studies have attempted to confirm the association between the recently reported polymorphism located at position −491 in the transcriptional reg... Abdel R.H Ahmed and...