Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among the increasing number of genetic risk factors identified, the apolipoprotein E (APOE) gene remains the strongest and most prevalent, impacting more t...
BEETSTRA-HILL, ALEXANDRAAustralasian College of Nutritional & Environmental Medicine Journal
9.Sonia Sanz Munoz, Brett Garner, Lezanne Ooi. Understanding the Role of APOE Fragments in Alzheimer’s Disease, Neurochemical Research 2019, 44(6):1297-1305. 10.Sarah A. Flowers, G. William Rebeck. APOE in the normal brain, Neurob...
更让人好奇的是,ApoE 和 HSV1 之间似乎有着千丝万缕的联系。流行病学研究发现,ApoE4(ApoE 的一种亚型)和 HSV1 “联手”,可能会增加患阿尔茨海默病(Alzheimer’s disease)的风险。然而,这两个 “小家伙” 在分子层面是如何互动的,却一直是个未解之谜。就像两个神秘的舞者,在黑暗的舞台上隐隐约约地舞动,却...
阿尔茨海默病(Alzheimer’s disease,AD)是病因复杂的神经退行性疾病。研究表明,遗传因素在AD的发生发展过程中扮演着重要角色,其发病机制涉及罕见的和常见的遗传变异【1】。三种基因,即APP、PSEN1和PSEN2的突变,会导致早发型常染色体显性遗传的阿尔茨...
2024年3月13日，来自美国斯坦福大学医学院的Tony Wyss-Coray团队在Nature上在线发表题为APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia的文章，通过对AD患者脑组织的单核RNA测序，发现了一种由脂滴相关酶ACSL1的表达所定义的小胶质细胞状态，其中ACSL1阳性的小胶质细胞在APOE4/4...
Alzheimer’s Disease (AD) is a complex, uniquely human condition that has eluded understanding and effective treatment for over a century. Nevertheless, dozens of transgenic (Tg) mouse models that recapitulate specific aspects of AD pathogenesis enable mechanistic interrogation and hypothesis testing impo...
2024年3月,斯坦福大学医学院的相关研究人员在《Nature》(IF: 64.8)上发表了题为“APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia”的研究论文,揭示了阿尔茨海默病的遗传风险因素与小胶质细胞脂滴积累和神经毒性小胶质细胞衍生因子之间的联系,可能为阿尔茨海默病提供治疗策略。
Topic:γ-Secretase and APOE in Alzheimer's Disease Speaker:Prof. Shi Yigong Date:Wednesday, Mar.13, 2024 Time:16:00-17:00 Venue:W201, Administration Building Language:English 嘉宾简介 Speaker Profile 施一公教授 中国科学院院士 西湖大学校长 ...
Alzheimer’s disease (AD) is the most common dementia. It is known that women with one ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we previously showed that follicle–stimulating hormone (FSH), a gonadotropin that rises in post–menopausal females, ...