ApoE 基因位于19号染色体，为载脂蛋白E的编码基因。ApoE主要是将甘油三酯和胆固醇运送到外周组织。载脂蛋...
Alzheimer's disease (AD) is the most common form of dementia that affects more than 5 million Americans. It is the only disease among the 10 causes of death that cannot be slowed or cured, thus raising the need for identification of early preclinical markers that could be the focus of pre...
ApoE 基因位于19号染色体，为载脂蛋白E的编码基因。ApoE主要是将甘油三酯和胆固醇运送到外周组织。载脂蛋...
Holland AJ: Apo E genotypes and risk of dementia in Down syndrome.Rubinsztein DC, Hon J, Stevens F, Pyrah I, Tysoe C, Huppert FA, Easton DF, Holland AJ. Apo E genotypes and risk of dementia in Down syndrome. Am J Med Genet. 1999; 88 (4):344–347. doi: 10.1002/(SICI)1096-...
Caffeine as a protective factor in dementia and Alzheimer's disease. Caffeine has well-known short-term stimulating effects on central nervous system, but the long-term impacts on cognition have been less clear. Dementia and... MH Eskelinen,M Kivipelto - 《Journal of Alzheimers Disease》 被引...
Altered brain white matter integrity in healthy carriers of the APOE ε4 allele A risk for AD? Background: Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impair... J Persson,J Lind,A Larsson,... - 《...
- 《Alzheimers & Dementia the Journal of the Alzheimers Association》 被引量: 0发表: 2011年 The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (...
近期,美国梅奥诊所的Chia-Chen Liu(第一作者,通讯作者)、卜国军(通讯作者)等人在Science Translational Medicine上在线发表了题为“APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia”的研究论文。该课题...
Apo E and Apo CI loci are associated with dementia in younger but not older late-onset cases. Numerous groups have confirmed that apolipoprotein E allelic variation accounts for a proportion of the genetic risk for late-onset Alzheimer’s disea... C Tysoe,D Galinsky,D Robinson,... - 《De...
This finding is in consonance with other studies that have shown that WMH volume is an independent risk factor for incident dementia [67], although not all studies have supported this result [52]. The independence of these factors is particularly interesting given the relationship of APOE with ca...