载脂蛋白E（APOE）参与机体血脂调节、胆固醇平衡、中枢神经系统受损神经元的修复等，具有重要生理学功能。...
Cody M. WolfeUniversity of Pittsburgh Pittsburgh PA USABrittany E. PlaysoUniversity of Pittsburgh Pittsburgh PA USAIliya LefterovUniversity of Pittsburgh Pittsburgh PA USARadosveta KoldamovaUniversity of Pittsburgh Pittsburgh PA USAJohn Wiley & Sons, LtdAlzheimer's & Dementia...
This finding is in consonance with other studies that have shown that WMH volume is an independent risk factor for incident dementia [67], although not all studies have supported this result [52]. The independence of these factors is particularly interesting given the relationship of APOE with ca...
The inheritance of ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer’s disease (AD) [1,2]. APOE is an apolipoprotein which, in the central nervous system, is secreted by glia; it facilitates the transport of cholesterol and phospholipids between...
- 《Alzheimers & Dementia the Journal of the Alzheimers Association》 被引量: 0发表: 2011年 Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease Apolipoprotein E (apoE) is critical in the modulation of cholesterol and phospholipid transport ...
The α-syn-rich proteinaceous deposits are not only found in PD but are also detected in other neurological disorders including dementia with Lewy bodies, some forms of Alzheimer's disease and multiple system atrophy [59–61]. Since α-syn is expressed in cell types other than neurons, often...
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementiaCase Report Open access Published: 15 July 2022 Volume 144, pages 589–601, (2022) Cite this article ...
is associated with amyotrophic lateral sclerosis- Parkinson dementia complex (ALS-PDC), a neurological disease affecting an indigenous population in Guam.18 NSC-34 motor neurons, a mouse–mouse hybrid cell line between neuroblastoma cells and spinal cord, were differ- entiated with 10 μM retinoic...
Laskowitz, et al., “Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production”, Neuroreport. 9(4):615-618 (1998). Laskowitz, et al., “Apolipoprotein E and the CNS response to injury”, Journal of Cerebral Blood Flow & Metabolism 18(5): 465-471 (1998). ...
Gene dose of the ε4 allele of apolipoprotein E and disease progression in sporadic late-onset alzheimer's disease A strong association has been described in cross-sectional studies between the ε4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD)... DGB Frisoni,S ...