Alzheimer's disease (AD) is the most common form of dementia that affects more than 5 million Americans. It is the only disease among the 10 causes of death that cannot be slowed or cured, thus raising the need for identification of early preclinical markers that could be the focus of pre...
Apo E genotypes and risk of dementia in Down syndrome. American Journal of Medical Genetics, 88, 344-347.Rubinsztein DC, Hon J, Stevens F, Pyrah I, Tysoe C, Huppert FA, Easton DF, Holland AJ. Apo E genotypes and risk of dementia in Down syndrome. Am J Med Genet. 1999;88:344-7....
Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's Disease Further to the wellestablished association between apolipoprotein E (APOE) and Alzheimer's disease, this gene has also been implicated in both susceptibili... CH Williams-Gray,A Goris,M Saiki,....
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- 《Alzheimers & Dementia the Journal of the Alzheimers Association》 被引量: 0发表: 2011年 Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease Apolipoprotein E (apoE) is critical in the modulation of cholesterol and phospholipid transport ...
This finding is in consonance with other studies that have shown that WMH volume is an independent risk factor for incident dementia [67], although not all studies have supported this result [52]. The independence of these factors is particularly interesting given the relationship of APOE with ca...
In order to quantify the effects of apolipoprotein (apo) E on early- and late-onset, sporadic and familial Alzheimer’s disease (AD) more precisely we... DC Rubinsztein,DF Easton - 《Dementia & Geriatric Cognitive Disorders》 被引量: 579发表: 1999年 Apolipoprotein E ε4 allele frequency is...
Circles represent females, squares represent males, diamonds represent individuals whose gender has been masked for privacy, arrowhead depicts proband individual with MCI and shading indicates individual with history of dementia. Deceased individuals are marked with a crossed bar.APOEgenotypes are indicated...
The α-syn-rich proteinaceous deposits are not only found in PD but are also detected in other neurological disorders including dementia with Lewy bodies, some forms of Alzheimer's disease and multiple system atrophy [59–61]. Since α-syn is expressed in cell types other than neurons, often...
is associated with amyotrophic lateral sclerosis- Parkinson dementia complex (ALS-PDC), a neurological disease affecting an indigenous population in Guam.18 NSC-34 motor neurons, a mouse–mouse hybrid cell line between neuroblastoma cells and spinal cord, were differ- entiated with 10 μM retinoic...