Diemer, N.H. & L. Klinken ( 1976 ): Astrocyte mitoses and Alzheimer type I and II astrocytes in anoxic encephalopathy . Neuropath. Appl. Neurobiol. 2 , 313 – 321 .Diemer NH , Klinken L ( 1976 ) Astrocyte mitoses and Alzheimer type I and II astrocytes in anoxic encephalopathy . ...
In the study of astrocyte calcium signaling in AD patients, the expression of inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) (also known as IP3 receptor type 2 (IP3R2)), an intracellular calcium release channel, was decreased in the astrocytes in brains of AD patients55,56. Further...
7,33. To test whether the spatial trajectories of astrocyte gene expression are also related to local Aβ and pTau levels, we correlated the average standardized expression of each of these spatial gene sets for each brain region
Define Alzheimer's. Alzheimer's synonyms, Alzheimer's pronunciation, Alzheimer's translation, English dictionary definition of Alzheimer's. Noun 1. Alzheimer's - a progressive form of presenile dementia that is similar to senile demen
[14]) have been grouped into type I and type II interferon-responsive phenotypes [15]. Microglial NF-κB signalling was identified as a central mediator of tau pathology in PS19 mice [16] (however, the failure to use appropriateCx3cr1CreERT2mice asCx3cr1haploinsufficiency controls [see ...
People with type II diabetes have an increased risk of developing Alzheimer’s disease. The connection is so strong that many scientists now refer to Alzheimer’s as “type III diabetes.”15 This is partly because chemical activity associated with increasedglucose levelshas now been directly tied ...
We next calculated the cell type scores (i.e., astrocyte, oligodendrocyte, microglia, etc) for each cell, which were represented by the average expression of a group of markers for each cell type.72 The cells were then selected as microglia/immune cells for further integrative analysis if ...
Class A receptors (SR-A) are expressed on microglia and astrocytes; class B scavenger receptor type 2 (also named as CD36) is expressed on microglia and endothelial cells [150], [151]. SR-A and CD36 have been associated with AD pathogenesis because both can bind and internalize Aβ, ...
Astrocyte heterogeneity: impact to brain aging and disease. Front. Aging Neurosci. 11, 59 (2019). Article CAS Google Scholar Rodríguez-Arellano, J., Parpura, V., Zorec, R. & Verkhratsky, A. Astrocytes in physiological aging and Alzheimer’s disease. Neuroscience 323, 170–182 (2016)....
et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev. Neurosci. 20, 291–299 (1998). Article CAS PubMed Google Scholar Benarroch, E. E. Brain glucose transporters: implications for neurologic disease. Neurology 82, 1374–1379 (2014). Article ...