Alzheimer type II astrocytesastrogliopathyhepatic encephalopathymetabolic encephalopathyp62Metabolic/hepatic encephalopathy is neuropathologically characterized by the presence of Alzheimer type II astrocytes (AA II) with large and clear nuclear morphology. To date, there is no good immunohistochemical marker...
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (AD)...
The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cel
The Alzheimer amyloid precursor is produced by type I astrocytes in glial cultures and displays a fibrillary distribution pattern : ∗N.K. Robakis, L.M. Refolo, D. Casper, M. Blum, F. Berkenbosch, V.L. Friedrich Jr. Mount Sinai School of Medicine, New York, NY 10029 USAShow more...
The apolipoprotein E gene (APOE, OMIM 107,741, chromosome 19q13.2) encodes a glycoprotein synthesized mainly in the liver, brain (primarily by neurons and astrocytes), and also by other cells such as macrophages and monocytes (Siest et al., 1995). APOE is involved in the mobilization and ...
Therefore, we characterized the neuro-immunologic milieu of APP/PS1 mice treated with FK506 by quantitating the number of GFAP-positive astrocytes and Iba1 + microglial cells in the cortex. Both showed significantly decreased numbers in FK506-treated APP/PS1 mice (Fig. 3D, E), consistent ...
Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis Proposed co-factors triggering the pathogenesis of multiple sclerosis (MS) are the Epstein Barr virus (EBV), and the potentially neuropathogenic MSRV (MS-...
Therefore, receptor-mediated internalization of Aβ in astrocytes might at least be partially affected by the presence of different APOE isoforms and APOE receptors, with APOE4 impairing the uptake of Aβ by these cells. Cellular uptake and degradation of Aβ by microglia is also differentially ...
J. The binding of insulin to cerebral capillaries and astrocytes of the rat. Neurochem. Res. 7, 489–494 (1982). Article CAS PubMed Google Scholar Garwood, C. J. et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular ...
Notably, glial cells, including astrocytes, microglia, and oligodendrocytes, are primarily implicated in early modules, whereas excitatory and inhibitory neurons are involved in both early, mid, and late modules. The functions of early modules are related to mitochondria, synapses, protein folding, ...