Alzheimer disease (AD) is the most common type of dementia, and is currently incurable; existing treatments for AD produce only a modest amelioration of symptoms. Research into this disease has conventionally focused on the CNS. However, several peripheral and systemic abnormalities are now understood...
Mass cytometry analysis of immune cells in the brain. Nat. Protoc. 13, 377–391 (2018). CAS PubMed Google Scholar Keren-Shaul, H. et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell 169, 1276–1290 (2017). This study uses single-cell ...
(permit number: 283/2012-B).OLE administration ameliorates memory dysfunction, raises a significant autophagic response in the cortex and promotes the proliferation of newborn cells in the subgranular zone of the dentate gyrus of the hippocampus.Our findings support the beneficial effects of EVOO ...
Accumulation and aggregation of amyloid {beta}-protein in late endosomes of Niemann-Pick type C cells J Biol Chem, 276 (2000), pp. 4454-4460 Google Scholar 52 H Runz, J Rietdorf, I Tomic, M de Bernard, K Beyreuther, R Pepperkok, T Hartmann Inhibition of intracellular cholesterol transpo...
Patients on medication for type 2 diabetes may be keeping Alzheimer's disease away, according to the study published in the journal Diabetes Care. "Our findings emphasize the importance of catching diabetes or other metabolic diseases in adults as early as you can," said Daniel A. Nation, a ...
The gene encodes a monomeric single-pass Type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells that mediates cellular binding to particles and immune complexes that have activated complement (Ahearn and Fearon, 1989). Three complement ...
Neuroblastoma X glioma hybrid NG108-15 cells were transfected to express stably either the wild-type human beta2-adrenoceptor or a constitutively active mu... DJ Macewan,G Milligan - 《Molecular Pharmacology》 被引量: 132发表: 1996年 Hydrogen Sulfide Inhibits A2A Adenosine Receptor Agonist Induced...
increased cytokine production, synaptic loss, and cognitive impairment and, importantly, did so without substantially affecting peripheral immune cell function as assessed by mitogen-induced, IL-2 mRNA expression from peripheral blood mononuclear cells (PBMC) harvested during therapy or splenocytes, harv...
H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer’s disease. Neurobiol. Aging 9, 339–349 (1988). Article CAS PubMed Google Scholar Merlini, M. et al. Extravascular CD3+ T cells in brains of ...
A protein that binds to and stabilizes microtubules within cells and is abundant in neurons. Humans express six isoforms of tau that result from alternative splicing of exons 2, 3 and 10 of the tau gene. Tau can be multiphosphorylated and this regulates its microtubule-binding properties. Apolip...