NogoR, (encoded by the RTN4R gene), is chiefly expressed in the central nervous exist and mediates interactions between the myelin sheath and neurons, and has been implicated in Alzheimer’s disease33. In this setting, NogoR interacts with Oligodendrocyte myelin glycoprotein (OMGP) and Nogo-A...
Relative EEG power analysis during the LC, active state (AS) of R1 showed a significant change in σ (4.143 ± 0.279% (Cav3.2+/+) vs. 5.300 ± 0.286% (Cav3.2−/−), p = 0.0118) (Fig.4C). No significant alterations were observed for δ1, δ2, α, θ1, ...
Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway. Front Aging Neurosci. 2022;14: 998292. Article CAS PubMed PubMed Central Google Scholar Luo P, Liu D, Zhang Q, Yang F, Wong YK, Xia ...
The nature of the search of primary memory by persons with a presumptive diagnosis of mild Alzheimer's disease (DAT) was compared with that of normal elderly and young persons using the Sternberg(l 966) paradigm. DAT subjects evidenced a substantial deficit in the speed of scanning in primary...
Metabolic syndrome and risk for incident Alzheimer’s disease or vascular dementia: the Three-City Study. Diabetes Care. 2009;32(1):169–74. https://doi.org/10.2337/dc08-0272. Article PubMed PubMed Central Google Scholar Solfrizzi V, Scafato E, Capurso C, D’Introno A, Colacicco AM...
Type-2 diabetes and neurodegenerative diseases such as Alzheimer's disease (AD) are linked and connected from a physio-pathological perspective due to oxidative stress and ROS (Fawole et al., 2012). AD, which is the most common form of dementia, is characterized by the accumulation of extracel...
Finally, one study used diffusion tensor imaging (DTI) features coupled with WM integrity analysis to distinguish between late-onset bipolar disorder, Alzheimer’s Disease (AD) and HC. Using an SVM algorithm trained and tested on fractional anisotropy (FA), the authors achieved 100% accuracy in ...
DNA methylation (DNAm) is one of the most widely studied epigenetic modifications that capture the cumulative effects of environmental and genetic factors. DNAm regulates cellular differentiation and gene expression and plays a key role in human development and disease etiology [1,2]. Single-nucleoti...
Intron-Exon Swapping of Transglutaminase mRNA and Neuronal Tau Aggregation in Alzheimer's Disease - ScienceDirect In order to understand the mechanism for insoluble neurotoxic protein polymerization in Alzheimer's disease (AD) brain neurons, we examined protein and gen... Bruce A. Citron §,Karen ...
L. et al. Alzheimer’s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience17, 1156–1163, https://doi.org/10.1038/nn.3786 (2014). Article CAS PubMed PubMed Central Google Scholar Ascoli, G. A., Donohue, D. E. & Halavi,...