T cells-protective or pathogenic in Alzheimer's disease? J. Neuroimmune Pharmacol. 10, 547-560.McManus RM, Mills KH, Lynch MA (2015) T cells-protective or pathogenic in Alzheimer’s disease? J NeuroImmune Pharmacol. : 10.1007/s11481-015-9612-2...
et al. Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self antigens in human m... neoplastic cells in the lymph nodes and/or increased tumor burden in metastatic disease activate CD8(+) T-cell-mediated antitumor immunity to self...
In vivo, clonal expansion of T cells during immune responses to both foreign and autoantigens is associated with telomere shortening. To investigate possible immune alterations in Alzheimer's disease (AD) that might impact current vaccine-based therapeutic strategies, we analyzed telomere lengths in ...
CD8+ T-cells Alzheimer’s disease RNAseq Synapse Npas4 Arc 1. Introduction Alzheimer’s disease (AD) is the most common form of dementia and characterized by an age-related neurodegeneration of the brain leading to a progressive cognitive decline (reviewed in Goedert and Spillantini 2006). Typ...
Here we investigated peripheral amyloid-beta1–42-specific T-cells by multicolor flow cytometry to simultaneously detect and characterize activation markers and cell signaling proteins (phospho-protein kinase C) in patients with Alzheimer's disease or Lewy body dementia and in healthy controls. Results...
53Citations 255Altmetric Metrics Abstract Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer’s disease (AD) pathology. To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model...
中文名称: Hs 934.T Cells|人黑色素瘤贴壁细胞 英文名称: Hs 934.T Cells 保存条件: 低温避光 纯度规格: 1×10(6)cells/T25培养瓶 产品类别: 实验试剂 "Hs 934.T Cells|人黑色素瘤贴壁细胞 89031-83-4 细胞背景资料:详见相关文献介绍 GIST-T1传代细胞实验平台;细胞生长特性:贴壁或悬浮,详见细胞...
Beta-amyloid (Aβ) plaque deposition in the brain is one of the hallmark pathologies of Alzheimer’s disease (AD). Microglia, the brain’s innate immune cells, clear Aβ plaques. As AD advances, microglia may gradually lose their ability to eliminate these plaques effectively, and, in turn...
Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegenerative diseases where c
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which neuroinflammation plays a critical function. Yet, little is known about the contribution of the adaptive immune response in AD. Here we used integrated analyses of multiple cohorts to identify peripheral and central adaptive ...