We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury. We find perivascular clustering of oligodendrocyte precursor cells (OPCs) in certain active MS lesions, representing an inability to properly detach ...
OligodendrogliaNeurodegenerationMALDI-MSCarbonic anhydrase IIMyelinIn Down syndrome (DS) as well as in Alzheimer's disease (AD) oligodendroglial and myelin ... Roman Vlkolinsk,N Cairns,M Fountoulakis,... - 《Neurobiology of Aging》 被引量: 176发表: 2001年 Oligodendroglia and neurotrophic fa...
Although nerve cell loss is prominent in certain brain regions in Alzheimer disease (AD), it is currently unresolved how these cells die. Recent studies unanimously agree that there are more neurons displaying DNA fragmentation in AD compared with normal controls. However, controversy remains...
Oligodendrocytes are a type of glial cells that play a critical role in supporting the central nervous system (CNS), in particular insulating axons within the CNS by wrapping them with a myelin sheath, thereby enabling saltatory conduction. They are lost, and myelin damaged – demyelination – in...
In embryonic brain, miR-125a-3p was found widespread in the whole parenchyma with a higher signal in the ventricular zone (Fig. 2c), where it mostly co-localized with Olig2, which, at this stage, labels a pool of precursor cells that will give rise to both OPCs and neurons21, ...
CONCLUSIONS Oxidative and nitrative stress have been closely associated with a large number of neurological disorders, in- cluding stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebral palsy, and multiple sclerosis. Approaches aimed at mainte- nance of zinc homeostasis...
In the brain, there were both WD-related lesions such as the scattering of Opalski cells and changes caused by hepatic encephalopathy including the appearance of Alzheimer type II glia. Of note, we identified copper deposits in the systemic organs, including hepatocytes, renal tubules, and in ...
Understanding these biological processes will help to identify specific pathways associated with this FTLD subtype and help in the development of new therapeutic strategies implicating oligodendroglial cells as a target to reduce the disease progression and improve quality of life of FTD with C9orf72 ...
Here, we discuss a potential dysfunction of RNA regulation in myelin diseases such as Multiple Sclerosis (MS) and Vanishing white matter disease (VWM) and potential contributions of OL dysfunction to neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) ...
Adult neurogenesis has been discovered by labeling mitotic cells of the brain with 5'-bromo-deoxyuridine (BrdU) or 3H-thymidine incorporation into nuclear DNA. This led to the identification of restricted neurogenesis areas in the adult brain, mainly dentate gyrus (DG) and subventricular zone (SVZ...