Glial cells and oligodendrocytes produced by reprogramming somatic cells with Sox10, Olig2 and Nkx6.2The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from ...
Glial cells can be divided into two general classes, microglia and macroglia. Microglia are macrophage type cells that are essentially the immune cells of the brain (Kreutzberg, 1996). Macroglia can be further divided into three categories: (1) ependymal cells, (2) oligodendrocytes, and (3)...
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Glial cells such as astrocytes and oligodendrocytes play crucial roles in the central nervous system. To investigate the molecular mechanisms underlying the development and the biological functions of glial cells, simple and rapid techniques for glial cell-specific genetic manipulation in the mouse cerebru...
(redirected fromOligodendroglial cells) Thesaurus Medical Encyclopedia ol·i·go·den·dro·cyte (ŏl′ĭ-gō-dĕn′drə-sīt′, ō′lĭ-) n. Any of the neuroglial cells of the central nervous system that are responsible for the formation of myelin sheaths in the white matter and ...
The study of the molecular and cellular biology of glial cells, for example, astrocytes, oligodendrocytes, Schwann cells and microglia. Featured Memory with a little H2O2help from astrocyte friends Rabah et al. elegantly show that, inDrosophila, astrocytes signal to neurons with hydrogen peroxide to...
Astrocytes and oligodendrocytes in the isolated intact mature rat optic nerve have been computer imaged in three dimensions by laser scanning confocal microscopy of single cells, dye-filled with lysinated rhodamine dextran (LRD). Our results illustrate the first application of these techniques to an ...
Unlike astrocytes and oligodendrocytes, Functions One of the well-known functions of glial cells is to help form an impermeable lining in the brain's capillaries and venules, the blood-brain barrier, that prevents toxic substances in the blood from entering the brain. In addition, glia control ...
As more molecular data are collected, classification of glia becomes more complex. In vertebrates, the term “glia” usually includes microglia and macroglia, i.e., radial glia, astrocytes, myelin-producing oligodendrocytes, and Schwann cells. There are several less numerous populations of glia, pa...