Blasco I, Humpel C and Grubeck‑Loebenstein B: Glial cells: astrocytes and oligodendrocytes during normal brain aging. In: Handbook of the Neuroscience of Aging. Hof PR and Mobbs CV (eds). Elsevier Academic Press, San Diego, CA, pp47‑52, 2009....
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity ...
In fact, immunolabeling of 5×FAD brain slices with the human APP-specific antibody, 1D1, revealed that human APP reactivity in neuronal soma is almost restricted to the cortex (Extended Data Fig. 8d) and hippocampus, confirming the Thy1.2 promoter domain. This further indicates that a ...
Cells with the most advanced cytoplasmic effacement expressed the C/EBP-homologous protein (CHOP). This protein is up-regulated as a late event in a cellular response termed the integrated stress response. This observation may link the cellular pathology observed in the brain with cellular stress ...
the first wave of fore- brain OPCs emerging from the medial ganglionic eminence and the anterior entopeduncular area might represent the most ''primitive source'' of oligodendrocytes, a relic that lost its importance during evolution, when new sources of OPCs developed in the expanding brain....
However, it remains unknown whether alterations of myelinated fibers in white matter differ from those in gray matter, whether myelin abnormalities are associated with aging, schizophrenia, and medication effects. Previously, we reported alterations of myelinated fibers in layer V of the prefrontal ...
Neuroinflammation and abnormal energy metabolism have been shown to significantly contribute to the progression of Alzheimer’s disease (AD). Adenylate kinase 5 (AK5), an enzyme predominantly expressed in the brain regulates ATP metabolism, has an unclear role in energy metabolism and neuroinflammation...
Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism. In this study we have investigated the fatty acid uptake and lipid biosynthesis in grey and white matter regions of the murine brain. Key findings were: (i) white matter oligodendrocytes and ...
Pharmacologically facilitating cholesterol transport increases axonal myelination and improves learning and memory in APOE4 mice. We provide a single-cell atlas describing the transcriptional effects of APOE4 on the aging human brain and establish a functional link between APOE4, cholesterol, myelination ...
Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposure increases the susceptibility of the neonat