Blasco I, Humpel C and Grubeck‑Loebenstein B: Glial cells: astrocytes and oligodendrocytes during normal brain aging. In: Handbook of the Neuroscience of Aging. Hof PR and Mobbs CV (eds). Elsevier Academic Press, San Diego, CA, pp47‑52, 2009....
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity ...
Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism. In this study we have investigated the fatty acid uptake and lipid biosynthesis in grey and white matter regions of the murine brain. Key findings were: (i) white matter oligodendrocytes and ...
the first wave of fore- brain OPCs emerging from the medial ganglionic eminence and the anterior entopeduncular area might represent the most ''primitive source'' of oligodendrocytes, a relic that lost its importance during evolution, when new sources of OPCs developed in the expanding brain....
Oligodendrocytes, the myelin-forming cells of the central nervous system, play important roles in brain development and maintenance. Activity-dependent neuroprotective protein (ADNP), an early marker essential for brain formation, interacts with microtubule end-binding proteins (EB1, EB2, and EB3). ...
- 《Brain Research》 被引量: 87发表: 2007年 Age-related decline in oligodendrogenesis retards white matter repair in mice. Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms of injury/repair i... N ...
course of brain development, perturbs the composition and physicochemical properties of brain cell membranes, neurones, oligodendrocytes, and astrocytes (2). ... JM Bourre - 《Journal of Nutrition Health & Aging》 被引量: 368发表: 2004年 Structure-Function Analysis of NADE IDENTIFICATION OF REGION...
The authors add, "Our study challenges the long-held belief that neurons are the exclusive source of amyloid beta in the brain, one of the key toxic proteins that builds up in Alzheimer's disease. "In fact, we show that oligodendrocytes, the myelinating cells of the central nervous system...
Gpr17 has been shown to be predominantly expressed in the oligodendrocyte lineage (Chen et al., 2009) but has also been reported in other cells types (Ren et al., 2015, Zhao et al., 2012). We performed a study to characterize the expression pattern of Gpr17 in the brain using Gpr17...
Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposure increases the susceptibility of the neonat