Alzheimer type II astrocytesastrogliopathyhepatic encephalopathymetabolic encephalopathyp62Metabolic/hepatic encephalopathy is neuropathologically characterized by the presence of Alzheimer type II astrocytes (AA II) with large and clear nuclear morphology. To date, there is no good immunohistochemical marker...
We sought to define the detailed cellular pathology of astrocytes, the extent of population variation and the relationship to Alzheimer-type changes in a population-based cohort. Three staining patterns were associated with GFAP and excitatory amino acid transporter 2 (EAAT2): minimal, moderate or ...
MiRNA dysregulation is also evident in AD and has been associated with several neuropathological alterations (Table2), including altered expressions of species that are known to be involved in AD pathology, including microglia and astrocytes (Shaik et al.2018). MiR-132/212 was reported to be d...
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Astrocytes Reactive astrocytes Alzheimer’s disease Dementia Neuroinflammation Neurodegeneration 1. Introduction Astrocytes are an abundant and highly ramified cell type in the brain with processes that ensheathe the cerebrovasculature as well as many, if not most, excitatory synaptic connections. Astrocytes...
The ApoE4 isoform is highly expressed in astrocytes under physiological conditions, but its expression is upregulated in microglia in mouse models of AD [95]. The effects of AβO at synapses are exacerbated by ApoE4 in plaque-bearing mouse models and human AD brain and are ameliorated by ...
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The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cel