Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol 2018;14:133–50. https://doi.org/10.1038/nrneurol.2017.188.Search in Google Scholar PubMed PubMed Central 31. Abbott, NJ, Rönnbäck, L, Hansson, E. Astrocyte-endothelial interactions at...
Advanced glycation end products (AGE) and the receptor for AGE (RAGE) have been implicated in the chronic complications of diabetes mellitus (DM), and have been reported to play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we established a polyclonal anti...
Canine distemper is a fatal disease in dogs, caused by a single-stranded, negative-sense RNA virus of the genusMorbillivirus, which is closely related to the human measles virus. The canine distemper virus (CDV) host range includes dogs and other canids, as well as ferrets, raccoons, bears,...
doi:10.1016/j.brainres.2009.12.039Amyloid-β with Dutch mutationApolipoprotein EInternalizationAccumulationCytotoxicityCerebral amyloid angiopathy (CAA) is a common pathological finding in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis of the Dutch type; in this latter condition it ...
Xia M, Yang L, Sun G, Qi S, Li B (2017) Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system. Psychopharmacology (Berl) 234(3):365–379. https://doi.org/10.1007/s00213-016-4473-9 Article CAS PubMed Go...
Very recent investigations in mouse models of tauopathies and Alzheimer’s disease suggested regulation of the complement 3 receptor (C3aR), that is abundant on astrocytes and microglia, rather than C3 itself as a feasible target for therapies aiming to reduce gliosis and formation of A1-astrocyte...
Astrocytic GABA is reported to be elevated in some conditions where reactive astrocytes are active, such as in Alzheimer's disease [88]. Furthermore, there is a redistribution of mBest1 expression in those reactive astrocytes from a mouse model of Alzheimer's [88], suggesting that GABA ...