Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging process that predispose the brain to the development of AD are largely unknown. Astrocytes perform a myriad of functions in the central nervous system to maintain homeostasis and support neuronal ...
Alzheimer's diseaseAstrocytesBlood-brain barrierSASPSenescenceSenolyticsSenescent astrocytes lose neuron-supportive function.Senescent astrocytes and other CNS cell types increase in Alzheimer's disease (AD).Targeting senescence in these cell types has reversed pathology in AD mouse models.Many drugs that ...
Bhat, R., et al., Astrocyte senescence as a component of Alzheimer's disease. PLoS One, 2012. 7(9): p. e45069.Crowe E, Bhat R, Bitto A, et al. Astrocyte senescence as a component of Alzheimer's disease. Exp Gerontol. 2013;48(7):695-696....