From cellular senescence to Alzheimer's disease: the role of telomere shortening. Ageing Res Rev 2015; 22: 1-8.Boccardi V., Pelini L., Ercolani S., Ruggiero C., Mecocci P. From cellu- lar senescence to Alzheimer's disease: The role of telomere shorten- ing. Ageing Res. Rev. 2015;...
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model. Nat. Neurosci. 22, 719–728 (2019). This paper shows that senescent OPCs accumulate around amyloid plaque deposition in samples of mice and human brains with...
Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for >95% of Alzheimer’s disease (AD) cases. The mechanism underlying the aging-related susceptibility to LOAD is unknown. Cellular senescence, a state of permanent cell growth arrest, is believed to...
Cellular senescence can be classified into two primary types: replicative and stress-induced premature senescence [4]. Replicative senescence primarily occurs due to telomere shortening and a decrease in telomerase activity, eventually leading to reaching the Hayflick limit [5]. Stress-induced premature ...
Astrocyte senescence as a component of Alzheimer’s disease. But is such an accumulation ‘good’ or ‘bad’ for the organism? There seems to no easy answer to this question considering the different faces of senescence [22]. Beneficial functions of senescence include limitation of the extent ...
Alzheimer's susceptibility [212] Protein processing Assembly of mitochondrial ribosomes and regulation of mitochondrial protein synthesis S: Substrates as part of the mAAA: respiratory chain subunits, mitochondrial ribosome subunit (MRPL32) Oxidative stress and senescence pathways mtUPR AFG3L2 (mAAA) ...
Alzheimer’s disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage. Free Radic. Biol. Med. 2013, 63, 115–125. [Google Scholar] [CrossRef] [Green Version] Zhang, H.; Davies, K.J.A.; Forman, H.J. Oxidative stress response and Nrf2 ...
Cellular senescence is a state of permanent cell cycle arrest that facilitates wound repair, tissue remodeling, and avoidance of cancer by halting proliferation in aged and damaged cells [10,11]. Senescence is associated with alterations in cell morphology, chromatin architecture, and the release of...
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been labeled as resilience and has evolved into a widely debated concept. External factors such as...
Aging is one of the major risk factors for many neurodegenerative diseases including Alzheimer's disease (AD). In AD, mitochondrial dysfunction and oxidative stress are highly associated with the progression of this brain pathogenesis [29]. Previously, our studies have revealed that overexpression (OE...