Alzheimer's diseaseGlobally, 50 million people live with dementia, with Alzheimer disease (AD) being responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia-related neurode
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model. Nat. Neurosci. 22, 719–728 (2019). This paper shows that senescent OPCs accumulate around amyloid plaque deposition in samples of mice and human brains with...
Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for >95% of Alzheimer’s disease (AD) cases. The mechanism underlying the aging-related susceptibility to LOAD is unknown. Cellular senescence, a state of permanent cell growth arrest, is believed to...
Rivera J, Gangwani L, Kumar S (2023) Mitochondria localized microRNAs: an unexplored miRNA niche in Alzheimer’s disease and aging. Cells 12(5):742. https://doi.org/10.3390/cells12050742 Article CAS PubMed PubMed Central Google Scholar Rodier F et al (2009) Persistent DNA damage signalling...
PC12 cellsb-Asarone Inhibits Amyloid-b by Promoting Autophagy in a Cell Model of Alzheimer’s Disease荧光3.8 卵母细胞和卵子Activity and intracellular localization of senescence-associated β-galactosidase in aging Xenopus oocytes and eggs荧光3 ...
Astrocytes acquire a senescent phenotype in Alzheimer’s disease patients while genetic clearance of senescent glia reduced gliosis, tau accumulation, and preserved cognitive function in a pre-clinical model of tauopathy (Bhat et al., 2012; Bussian et al., 2018). Similarly, administration of dasa...
In addition, it has been observed that SLC1A4 protein expression in isolated brain microvessels and brain prefrontal cortices in 5xFAD mice (Alzheimer’s disease) was twice as high as that in wild-type (WT) controls [40]. Our sequencing results showed that SLC1A4 was substantially up...
During acute and high doses of nucleic acid damage, the rapid sensing of RNA lesions by translating ribosomes activates the RNA damage response. During chronic and low doses of nucleic acid damage, the DNA damage response prevails, promoting DNA repair or inducing senescence to prevent the ...
[263]. This topic is also directly linked to several age-related diseases, such as Parkinson’s disease, Alzheimer’s disease, cancer, and other degenerative diseases. It is known that mitochondrial function decreases in several types of adult stem cells, but it remains unclear whether all ...
Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell. 2015; 17:204–12. https://doi.org/10.1016/j.stem.2015.07.006 PMID:26253202 76. Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory ...