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This senescence response occurs immediately after certain insults, such as genotoxic stress ormetabolic shock, triggered in cells by culture conditions. Oncogenic stress triggered by theoverexpression of certain oncogenesor loss of tumor suppressor genes (TSGs) in primary and tumor cells also induces ...
B. Noncell-Autonomous Regulation of Senescence in Cancer: Role of SASP SASP对于肿瘤的形成来讲是一把双刃剑 senescent cells can induce paracrine senescence in neighboring cells, thus acting as a barrier against tumor growth.;SASP can activate immune surveillance and bring innate and adaptive immune r...
Cellular Senescence in Cancer and Aging Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepress... M Collado,MA Blasco,M Serrano - 《Cell》 被引量: 2386发表: 2007年 Cancer, aging and cellular ...
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细胞衰老 (cellular aging ,cell senescence ) 相关知识点: 试题来源: 解析 衰老是机体在退化时期生理功能下降和紊乱的综合表现 , 是不可逆的生命过程。 细胞衰老是细胞生理与生化反应发生变化的过程,主要表现是细胞对环境变化适应 能力和维持细胞内环境恒定能力的降低,导致细胞形态结构和功能上发生一系列的 变化。对...
Cellular senescence in cancer and aging Cell (2007) L. Hayflick et al. The serial cultivation of human diploid cell strains Exp. Cell Res. (1961) D.J. Baker et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan Nature (2016) D.J. Baker et al. Clearance of p16...
百度试题 题目cellularaging,cellsenescence(细胞衰老) 相关知识点: 试题来源: 解析 是机体在退化时期生理功能下降和紊乱的综合表现,是不可逆的生命过程。人体是由细胞组织起来的,组成细胞的化学物质在运动中不断受到内外环境的影响而发生损伤,造 反馈 收藏 ...
Baicalin is a natural flavonoid glycoside which has potent anti-tumor and antioxidant activity in cancer cells. In the present study, we found that baicalin treatment significantly induced senescence in colon cancer cells. Furthermore, baicalin upregulat