为了和Aging区分,咱们暂且称senescenece为老化,senescent cells就是老化细胞,很多地方也翻译成衰老细胞。老化细胞是指细胞周期停滞,但抗凋亡,还向周围产生分泌因子SASP(老化细胞相关分泌表型)的“僵尸细胞”。SASP的类型包括细胞因子、趋化因子、促纤维化生长因子、脂质、外泌体等,SASP通常产生促炎效应。细胞老化也是衰老...
However, the untoward effect is that the accumulation of senescent cells promotes loss of resilience, aging and age-related diseases. One approach to maintaining the benefits of senescence while preventing the negative consequences is senolytic therapies: drugs that do not prevent senescence, but ...
A quantitative analysis of the aging of human glial cells in culture. J. Cell. Physiol. 117, 342–352 (1983). CAS PubMed Google Scholar Cristofalo, V. J. & Sharf, B. B. Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid ...
Senescent cells that accumulate in tissues activate the immune system by secreting SASP factors. The activated immune system is believed to maintain tissue homeostasis by removing senescent cells3. In aging and pathological conditions, this removal mechanism becomes dysfunctional (anergy) and senescent cel...
To limit the detrimental properties while retaining the beneficial aspects of senescent cells, research advancements that support screening, design and optimization of anti‐aging therapeutic agents are in rapid progress in the setting of prospective development of clinical strategies, which together ...
Cells that permanently stop dividing have long been recognized as one of the body's defenses against cancer. Now they are also seen as a sometime culprit in cancer and a cause of aging
Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that target senescent cells, broadly
Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialyl
Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It has been proposed that senescent cells damaged cells that have lost the ability to divide drive the deterioration that underlies aging and age-related diseases. However, definitive evidence for this relat...
Senescent cells display a PDK4-dependent increase in aerobic glycolysis and enhanced lactate production but maintain mitochondrial respiration and redox activity, thus adopting a special form of metabolic reprogramming. Medium from PDK4+ stromal cells promotes the malignancy of recipient cancer cells in ...