Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.doi:10.1016/j.tibs.2020.03.008Shuling Song...
A quantitative analysis of the aging of human glial cells in culture. J. Cell. Physiol. 117, 342–352 (1983). CAS PubMed Google Scholar Cristofalo, V. J. & Sharf, B. B. Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid ...
为了和Aging区分,咱们暂且称senescenece为老化,senescent cells就是老化细胞,很多地方也翻译成衰老细胞。老化细胞是指细胞周期停滞,但抗凋亡,还向周围产生分泌因子SASP(老化细胞相关分泌表型)的“僵尸细胞”。SASP的类型包括细胞因子、趋化因子、促纤维化生长因子、脂质、外泌体等,SASP通常产生促炎效应。细胞老化也是衰老...
1. Role of Senescent cells in Aging A. What is Aging? "The greatest trick the devil ever pulled was convincing the world he didn't exist." The medical profession tries to convince the world that nobody dies from aging, aging is not a disease and aging is just a normal healthy ...
Scientists show that so-called senescent cells, i.e., cells that have permanently stopped dividing, boost production of new muscle cells to enhance regeneration of lost limbs in salamanders. Senescent cells, linked to aging and disease, may also have regenerative properties. Studying salamanders, re...
Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun. 2018;9(1):5435. doi:10.1038/s41467-018-07825-3... - 《Nature Communications》 被引量: 3发表: 2018年 Immune surveillance of senescence: potential application to age-related diseases Impaired immune surve...
To limit the detrimental properties while retaining the beneficial aspects of senescent cells, research advancements that support screening, design and optimization of anti‐aging therapeutic agents are in rapid progress in the setting of prospective development of clinical strategies, which together ...
Cellular senescence is recognized as an evolutionarily conserved process in tumor suppression, wound healing and regeneration. However, the accumulation of senescent cells during aging can contribute to age-related diseases1,2,3,4,5,6,7,8. Cellular senescence is characterized by an essentially permane...
Now, scientists have shown for the first time that an FDA-approved antibiotic – Azithromycin – can effectively target and eliminate senescent cells in culture. Publishing in the journalAging(US), a team from the University of Salford's Translational Medicine Laboratories compared the effects of a...
Cellular senescence represents a distinct cell fate characterized by replicative arrest in response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming during development and wound healing, while limiting tumorigenesis. However, pathologic accumulation of senescent cells is implicat...