Nooden LD (1988) The phenomenon of senescence and aging. In: Nooden LD, Leopold AC (eds) Senescence and aging in plants. Academic, London, pp 1–50Nooden, L.D. 1988. The phenomenon of senescence and aging. In Senescence and Aging in Plants. L.D. Nooden and A.C. Leopold, ...
Here, we review current knowledge of the innate immune response to SARS-CoV-2 infection and the various means SARS-CoV-2 employs to evade innate defense systems. We also consider the role of innate immunity in SARS-CoV-2 vaccines and in the phenomenon of long COVID....
Furthermore, as gerontologists borrowed the cultural agendas as well as research methods from studies of growth, aging began to be defined as a phenomenon that could be actively controlled and managed in both social arenas and laboratory environments. 展开 关键词:...
Understanding how and why menopause has evolved is a long-standing challenge across disciplines. Females can typically maximize their reproductive success by reproducing for the whole of their adult life. In humans, however, women cease reproduction several decades before the end of their natural life...
First, using his "immortal" tissues, he asserted that aging was a contingent phenomenon that could be experimentally manipulated. Although this claim was eventually challenged, it prompted many scientists to think that aging was not so much an unavoidable, unidirectional phenomenon as a process ...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associa...
The phenomenon of an "increasing mortality with increasing chronological age in populations in the wild" ("IMICAW" [Libertini, 1988]), alias "actuarial senescence in the wild" [Holmes and Austad, 1995], alias "age-related fitness decline in the wild", is a real and well documented ...
To the best of our knowledge, this is the first report of this phenomenon in the literature. Although there was no apparent direct association between the number of mitochondria in oocytes and chronologic age, basal FSH level and total number of oocytes retrieved were found to be major ...
Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immu
, we consider how interventions that target either metabolism or senescent cells might influence each other and mitigate some of the pro-aging effects of cellular senescence. We conclude that the most effective interventions will likely break a degenerative feedback cycle by which cellular senescence ...