This article explores the challenges in defining cellular senescence, which is the process of aging and the loss of cell division ability. Senescent cells have specific characteristics, but there is currently no single marker to definitively identify them in humans. The SenNet consortium was ...
Changes of MNC energy status during aging. Graph shows the ATP/AMP ratio, as a marker of the energy status of MNC isolated from peripheral blood (PB), obtained from healthy population with an age between 5 and 106 years. The population is divided by decades. The values decrease progressively...
The quest to define senescence This article explores the challenges in defining cellular senescence, which is the process of aging and the loss of cell division ability. Senescent cells ... Esterly, Allen T.,Zapata, Heidi J. - Frontiers in Genetics 被引量: 0发表: 2024年 ...
3a). HT-29 cells harboring drug addiction variants showed an altered cell morphology and increased β-galactosidase staining in the absence of drug, indicating increased senescence, which was also reversed with drug treatment (Fig. 2f and Extended Data Fig. 3b). These data support the hypothesis...
Screens were split into drug treatment arms or control arms for a further 11 days, with passaging or refreshing drug every 3–4 days. Drug concentrations were based on IC50 from GDSC19 and confirmed empirically using CellTitre-Glo (CTG) proliferation drug titration assays. Drug ...
One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of senescence that includes a shortened lifespan and...
Inflammation, aging, and cancer: Tumoricidal versus tumorigenesis of immunity. Cell Biochem. Biophys. 2009, 55, 55–79. [CrossRef] [PubMed] 82. Hemila, H.; Chalker, E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst. Rev. 2013, 1. [CrossRef] 83. Moser,...