今天给大家翻译下2023年1月,西班牙奥维耶多大学的Carlos López-Otín和法国古斯塔夫鲁西研究所的Guido Kroemer等人在Cell上发表的“Hallmarks of aging: An expanding universe”综述文章。作者在2013年综述的基础上又总结了近十年来衰老特征研究的新成果,进一步定义并详细阐述了衰老的十二个特征,为未来探索衰老过程和开发新...
Next, we will focus on the different hallmarks of cellular senescence and cellular ageing, and the detection techniques most suitable for immune cells. Applying these techniques will deepen our understanding of immune cell senescence and to discover potential druggable pathways, which can be modulated ...
R. et al. Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging. Endocrinology 155, 2287–2300 (...
The Hallmarks of Aging Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deteriorat... C López-Otín,MA Blasco,L Partridge,... - 《Cell》 被引量: 3675发表: 2013年 Hallmarks of senescence in carcino...
aging have been summarized under the term the “hallmarks of aging” and include a loss of proteostasis, mitochondrial dysfunction, altered nutrient sensing, telomere attrition, genomic instability, cellular senescence, stem cell exhaustion, epigenetic alterations and altered intercellular communication. We ...
119. Kowald A, Passos JF, Kirkwood TBL. On the evolution of cellular senescence. Aging Cell 2020;19:e13270. 120. Lee S, Schmitt CA. The dynamic nature of senescence in cancer. Nat Cell Biol 2019;21:94–101. 121. ...
展开 关键词: [biochemical pathways, stem cells, risk factors, death, telomeres, cardiovascular diseases, evolution, human health, epigenetics, neurodegenerative diseases, cell communication, adverse effects, diabetes, humans, cell senescence] DOI: 10.1093/geroni/igab046.1969 被引量: 1306 年份...
TheHallmarksofAging 续篇(二) 这九项特征为:基因组失稳(genomic instability)、端粒损耗(telomere attrition)、表观遗传学改变(epigenetic alterations)、蛋白质稳态丧失(loss of proteostasis)、营养素感应失调(deregulated nutrient sensing)、线粒体功能障碍(mitochondrial dysfunction)、细胞衰老(cellular senescence)、干...
119. Kowald A, Passos JF, Kirkwood TBL. On the evolution of cellular senescence. Aging Cell 2020;19:e13270. 120. Lee S, Schmitt CA. The dynamic nature of senescence in cancer. Nat Cell Biol 2019;21:94–101. 121. Wang B, Kohli J, Demaria M. Senescent cells in cancer therapy: fri...
He concludes this review by discussing the common hallmarks of cancer, aging and cell senescence, stating, "In organismal aging, cancer andcellular senescence, the same key signaling pathways, such as mTOR, are involved. This is why the same drugs, such as rapamycin, can suppress all of them...