内容提示: Leading EdgeReviewThe Hallmarks of AgingCarlos Lo ´pez-Otı ´n,1Maria A. Blasco,2Linda Partridge,3,4Manuel Serrano,5,* and Guido Kroemer6,7,8,9,101Departamento de Bioquı ´mica y Biologı ´a Molecular, Instituto Universitario de Oncologı ´a (IUOPA), ...
Nutrient depletion, which is one of the physiological triggers of autophagy, results in the depletion of intracellular acetyl coenzyme A (AcCoA) coupled to the deacetylation of cellular proteins. We found that there are at least 4 possibilities to mimic these effects, namely (i) the depletion ...
aginghallmarkscancercellularcniopartridge LeadingEdgeReviewTheHallmarksofAgingCarlosLo´pez-Otı´n,1MariaA.Blasco,2LindaPartridge,3,4ManuelSerrano,5,*andGuidoKroemer6,7,8,9,101DepartamentodeBioquı´micayBiologı´aMolecular,InstitutoUniversitariodeOncologı´a(IUOPA),UniversidaddeOviedo,...
The Hallmarks of Aging 来自 iAcademic 喜欢 0 阅读量: 361 作者: López-Otín, Carlos,Blasco, Maria A.,Partridge, Linda,Serrano, Manuel,Kroemer, Guido 摘要: Nutrient depletion, which is one of the physiological triggers of autophagy, results in the depletion of intracellular acetyl coenzyme A ...
Here, we have attempted to identify and categorize the cellular and molecular hallmarks of aging. We propose nine candidate hallmarks that are generally considered to contribute to the aging process and together determine the aging phenotype (Figure 1). Given the complexity of the issue, we have ...
The hallmarks of aging. Cell 153, 1194–1217 (2013). Article PubMed PubMed Central CAS Google Scholar Kennedy, B. K. et al. Geroscience: linking aging to chronic disease. Cell 159, 709–713 (2014). Article CAS PubMed PubMed Central Google Scholar Kiss, T. et al. Single-cell RNA...
本篇综述来源于《cell》2013. The hallmarks of aging. Cell. 153:1194–1217,试图将不同生物体(特别是哺乳动物)的衰老归纳为九项共性特征。 这九项特征为:基因组失稳(genomic instability)、端粒损耗(telomere attrition)、表观遗传学改变(epigenetic alterations)、蛋白质稳态丧失(loss of proteostasis)、营养素感...
importance of aging research for an understanding of different biological and medical issues, a key question here is to what extent these nine hallmarks of aging represent the “causes of aging”. In other words, on which foundational evidence and assumptions have the “hallmarks of aging” been...
W. Deiodinases: implications of the local control of thyroid hormone action. J. Clin. Invest. 116, 2571–2579 (2006). Article CAS PubMed PubMed Central Google Scholar Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding ...
The hallmarks of aging. Cell 153, 1194–1217 (2013). This paper reviews the evidence for nine key mechanisms that are characteristic of mammalian ageing. Article PubMed PubMed Central CAS Google Scholar Partridge, L., Deelen, J. & Slagboom, P. E. Facing up to the global challenges of...