Such changes in phenotype have the potential to contribute to human ageing and age-related diseases. Until now, senescence has largely been studied as an in vitro phenomenon, but recent data have for the first time directly demonstrated the presence of senescent cells in aged human tissues. ...
Such changes in phenotype have the potential to contribute to human ageing and age-related diseases. Until now, senescence has largely been studied as an in vitro phenomenon, but recent data have for the first time directly demonstrated the presence of senescent cells in aged human tissues. ...
D. Di Fagagna, “Cellular senescence in ageing: from mechanisms to therapeutic opportunities,” Nature Reviews. Molecular Cell Biology, vol. 22, no. 2, pp. 75–95, Dec. 2020, doi: 10.1038/s41580-020-00314-w. Available: https://pubmed.ncbi.nlm.nih.gov/33328614/...
Infection as a Cause of Cancer Helicobacter as a cause of Gastric Cancer Host Immune Response The Association of Inflammation and Cancer What does the Chronic Inflammatory Environment Look Like? What are the Long-Term Effects of Chronic Inflammation? Inflammation and Tumours: Inflammation’s Many Role...
. Senile dementia, we called it then. The grandma I had known — never less than immaculately coiffed and dressed, a shrewd and knowledgeable collector of antiques, and a baker of puddings so sublime I can taste them to this day — slowly disappeared into the netherworld of senescence....
By preventing cells from reaching senescence one can achieve biological immortality; telomeres, a "cap" at the end of DNA, are thought to be the cause of cell aging. Every time a cell divides the telomere becomes a bit shorter; when it is finally worn down, the cell is unable to split...
Such staggering multilevel diversity in manifestation of senescence precludes (without methodology of systems biology) development of a correct understanding of its primary causes and does not allow for developing approaches capable of postponing ageing or reducing organisms' ageing rate to attain health ...
While it remains clear that excessive levels of oxygen species are detrimental and can be a cause of disease, further studies will be necessary to clarify how hypoxia can influence such levels. 2.4. Cellular senescence Cellular senescence was initially described as the finite lifetime of diploid ce...
Cell senescence: role in aging and age-related dis- eases. Interdiscip Top Gerontol. 2014;39:45–61. 30. Stolzing A, Jones E, McGonagle D, et al. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing...
(Man et al., 2014, Marques et al., 2013)) and the cells belonging to the respective organ system also alter their functionality, entering into senescence or displaying reduced proliferation capacity (Moorefield et al., 2017, Rawji et al., 2016)). This, on one hand, intensifies the entry...