Aging - Senescence, Mammals, Longevity: The lean body mass, consisting of the skeletal muscles and all other cellular tissues, decreases steadily after physical maturity until, in extreme old age, it may be reduced to two-thirds its value in young adults
The model has been criticized, largely because few understand what the model actually says about aging. The cell senescence model (often mislabeled the "telomere theory of aging") suggests that changes in gene expression within senescent cells underlie most common age-related pathology, for example ...
The antagonistic pleiotropy theory for the evolution of senescence... A.,Charmantier,C.,... - 《Proceedings of the National Academy of Sciences》 被引量: 261发表: 2006年 HISTOLOGY AND PATHOLOGY OF THE HUMAN INTERVERTEBRAL DISC. Cells in herniated discs appear to have a higher degree of ...
Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298–300. CAS Google Scholar Harman D . The biologic clock: the mitochondria? J Am Geriatr Soc 1972; 20: 145–147. CAS Google Scholar Gough DR, Cotter TG . Hydrogen peroxide: a Jekyll and Hyde ...
One theory claims that aging is related to an accumulation of age-related mutations, or cells that are no longer being repaired or dividing. However, the pleiotropic antagonism theory is associated with the late effects of specific genes. The third theory is based on survival research done on...
Since publication of the article, "Developmental Theory of Aging Revisited: Focus on Causal and Mechanistic Links Between Development and Senescence," (Walker RF. Rejuvenation Res 14(4):429-436, 2011), it has been argued that the hypothe... RF Walker - 《Rejuvenation Research》 被引量: 0发...
growth, development, senescence and aging ‐ life history perspectivelife history theory ‐ study of evolution and function of life stages and of behaviors related to these stageshumans, showing unique patterns of growth within different tissues and dimensions...
17.Williams' idea, now known as the antagonistic pleiotropy theory of aging, remains the prevailing evolutionary explanation of senescence, the process of becoming old or aging. 18.This was the first link between the molecular biology of telomeres and cellular senescence, the aging and death of ...
The classic evolutionary theory of aging explains why mortality rises with age: as individuals grow older, less lifetime fertility remains, so continued survival contributes less to reproductive fitness. However, successful reproduction often involves intergenerational transfers as well as fertility. In the...
1 Aging(老化) Senescence(衰老) 老化是條不歸路,每個人都希望自己能走 得慢一點,然而走得快樂一點或許才是最 好的抗老防衰之道。 從十九世紀開啟老化研究至今,我們對老 化的定義、過程、已經有了初步的了解, 例如:老化與基因的關係、自由基理論以 及荷爾蒙、營養素、運動…...