cellular senescencedeleteriomeevolutionary biologylifespanmolecular damagetheories of agingUnderstanding the aging process and ways to manipulate it is of major importance for biology and medicine. Among the many aging theories advanced over the years, the concept most consistent with experimental evidence ...
A test of evolutionary theories of senescence. Nature 287, 141–142 (1980). This study demonstrates that delaying the age of reproduction for several generations extends lifespan. Article ADS CAS PubMed Google Scholar Friedman, D. B. & Johnson, T. E. A mutation in the age-1 gene in ...
Senescence-accelerated mice (SAM) are a series of inbred strains developed from the AKR/J strain, consisting of 9 senescence-prone strains (SAMP) and 4 senescence-resistant strains (SAMR) [2, 3]. Compared with SAMR strains, which show normal senescence, SAMP strains exhibit accelerated-...
G. Bell Evolutionary and nonevolutionary theories of senescence Am. Nat., 124 (1984), pp. 600-603 https://doi.org/10/bz2mxx View in ScopusGoogle Scholar Blum and Payne, 2019 P. Blum, S. Payne Evidence of an epigenetics system in Archaea Genet. Epigenet., 12 (2019), Article 251686571...
(Shane2005; McGrath2016), based on such things as obsolescence or degradation of buildings and infrastructure, changes in economic drivers and opportunities, growth and senescence of urban plantings, new technologies, and social and demographic shifts in density and use. Depending on local and ...
Classical theories for the evolution of senescence predict that organisms that experience low mortality rates attributable to external factors, such as disease or predation, will evolve a later onset of senescence. Here we use patterns of senescence in guppies derived from natural populations that diffe...
Depending on the extent of UV- induced molecular changes, it can impair signal transduction pathways related to differentiation, inflammation and senescence [13]. The mitogen-activated protein kinase (MAPK) can directly be activated by ROS [13]. Ultimately, transcription factor complexes (AP-1 and...
heterogeneity and functional states of these cells is still controversial in the field, data generated using single-cell technologies have led to a rapid increase in new theories and research directions related to how we can understand the complexity of these cells and how we might target these ce...
This is particularly important when considering the potential reversibility and plasticity of senescence, and environmental effects, such as circumstances early in life. • There is a need to reconcile the different approaches to studying senescence, and to integrate theories to explain ...
Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual’s health and survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to heavily process sensory information. To adapt to an animal’s needs, OB activity can be influen...