PP2A activation has been shown to reverse cellular senescence in non-cancerous pathologies, therefore we hypothesized that reactivation of PP2A using novel small molecule activators would function as a novel senotherapeutic in NBL.Methods:We employedMYCNamplified, SK-N-BE(2), and non-amplified, SK...
they found that the decision to enter senescence was made within 12 hours of DNA damage, even though it took days to actually see the senescent cells accumulate. The team also found that with the passage of more time, these MAP kinases took on a...
1997: Making Sense of Senescence (Molecular Genetic Regulation and Manipulation of Leaf Senescence) Plant Physiology 113(2): 313-319 Saitoh, K.; Inamura, R.; Ishihara, K. 1994: Relationship between leaf movement of trifoliolate compound leaf and environmental factors in the soybean canopy: IV....
Concerns are heightened by the recent introduction and widespread use of carboxamides which offers unprecedented levels of disease control, delays in senescence and yield responses. Grain yield has often been found to be negatively associated with GPC, but this relation is not true for a single ...
Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases, including cardiovascular disease and cancer. Various age-related DNA methylation changes have been described,
in which case it may bear the features of replicative senescence. In the absence of adequate survival factors, p53 will be more likely to drive apoptosis, although, as discussed below, the ability of p53 to do so relies also to a great extent on its likelihood to turn on particular molecul...
Role of oxidative carbonylation in protein quality control and senescence. EMBO J. 2005, 24, 1311–1317. [CrossRef] [PubMed] 119. Yokota, T.; Kinugawa, S.; Yamato, M.; Hirabayashi, K.; Suga, T.; Takada, S.; Harada, K.; Morita, N.; Oyama-Manabe, N.; Kikuchi, Y.; et al....