transcription factor GATA4, acting upstream of NF-B, is also required for senescence establishment and SASP induction bromodomain and extraterminal domain (BET) family member bromodomain-containing protein 4 (BRD4) that positively regulates the senescence secretome and promotes senescence immune clearan...
B. Noncell-Autonomous Regulation of Senescence in Cancer: Role of SASP SASP对于肿瘤的形成来讲是一把双刃剑 senescent cells can induce paracrine senescence in neighboring cells, thus acting as a barrier against tumor growth.;SASP can activate immune surveillance and bring innate and adaptive immune ...
Provinciali M, Cardelli M, Marchegiani F and Pierpaoli E: Impact of cellular senescence in aging and cancer. Curr Pharm Des 19: 1699-1709, 2013.Provinciali M, Cardelli M, Marchegiani F, Pierpaoli E: Impact of cellular senescence in aging and cancer. Curr Pharm Des 2013, 19 (9) : ...
Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729–740 (2007). Article CAS Google Scholar Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223–233 (2007). Article CAS PubMed Google Scholar ...
# 细胞衰老(cell aging),是指细胞在执行生命活动过程中,随着时间的推移,细胞增殖与分化能力和生理功能逐渐发生衰退的变化过程。 == 细胞的生命历程都要经过未分化、分化、生长、成熟、衰老和死亡几个阶段。 == 衰老死亡的细胞被机体的免疫...
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656–660 (2007). Article CAS PubMed PubMed Central Google Scholar Kang, T.W. et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479, 547–...
For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function...
细胞衰老(cell aging)是指细胞在执行生命活动过程中,随着时间的推移,细胞增殖与分化能力和生理功能逐渐发生衰退的变化过程。细胞的生命历程都要经过未分化、分化、生长、成熟、衰老和死亡几个阶段。衰老死亡的细胞被机体的免疫系统清除,同时新生的细胞也不断从相应的组织器官生成,以弥补衰老死亡的细胞。细胞衰老死亡与新...
# 细胞衰老(cell aging),是指细胞在执行生命活动过程中,随着时间的推移,细胞增殖与分化能力和生理功能逐渐发生衰退的变化过程。 == 细胞的生命历程都要经过未分化、分化、生长、成熟、衰老和死亡几个阶段。 == 衰老死亡的细胞被机体的免疫系统清除,同时新生的细胞也不断从相应的组织器官生成,以弥补衰老死亡的细胞。
72–74 Several studies have suggested that Senescence plays an important role in Aging and age-related diseases such as tissue degeneration, various diseases including cancer.74 Conditions such as mitochondrial dysfunction, telomere alteration, DNA damage, and epigenetic factors play a crucial role in ...