Astrocytes are a particular type of glial cells observed throughout the gray matter in the brain. In a healthy brain, they help to defend evolutionarily conserved astrogliosis programs and maintain neuronal metabolism. On the other hand, in the Alzheimer's disease (AD) affected brain, they ...
beta-amyloid is the primary protein component of neuritic plaques, which are degenerative foci in brains of patients with Alzheimer\u27s disease (AD). The effects of this naturally occurring beta-amyloid on the cells of the central nervous system have not been completely understood. The effect of...
This review describes the role of M and astrocytes in the pathogenesis of these three progressive neurological diseases, examining both beneficent and deleterious effects in each disease. 展开 关键词: Macrophage/microglia Astrocytes HIV-associated dementia Alzheimer disease Multiple sclerosis ...
et al. Ca(21) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid beta-treated astrocytes and in a model of Alzheimer's disease. Aging Cell 12, 292–302, doi:10.1111/acel.12054 (2013). 24. Johnson, S. C., Rabinovitch, P. S. & Kaeberlein, M. ...
Prolactin has been shown to favor both the activation and suppression of the microglia and astrocytes, as well as the release of inflammatory and anti-inflammatory cytokines. Prolactin has also been associated with neuronal damage in diseases such as multiple sclerosis, epilepsy, and in experimental ...
in (a) OMIM and (b) GWAS, DECIPHER and DIsGeNet. Checkmarks indicate the presence of the disease with that particular protein in any the databases. Abbreviations: bipolar disorder (BPD), Alzheimer’s disease (ALZ); autism spectrum disorders (ASD); amyotrophic lateral sclerosis (ALS); ...
Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease ArticleOpen access14 June 2022 Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission ArticleOpen access Involvement of dopaminergic signaling in the cross talk between the ...
blood–brain barrier; Alzheimer’s disease; neuroinflammation; neurodegenerative disorders; amyloid plaques; astrocytes 1. Introduction The blood–brain barrier (BBB) is a complex neurovascular structure responsible for the control of neural homeostasis through the selection of molecules that can reach the...
The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 8972. https://doi.org/10.3390/ijms23168972 AMA Style Sun E, Motolani A, Campos L, Lu T. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of ...
These cells exist both in the developing and the adult nervous systems of all mammalian organisms. They have the ability to self-renew, migrate to diseased areas of the brain and differentiate into neurons, astrocytes and oligodendrocytes. The migratory ability of NPCs and their capacity to ...