h, Cortical astrocyte populations match astrocyte states identified in the hippocampus. Heat map showing the correspondence between the de novo cluster IDs (rows, from (e)) of the cross regional dataset, and the predicted cluster IDs (columns) using the hippocampal astrocytes cluster IDs as ...
In summary, these studies define an epigenetically controlled memory astrocyte subset that promotes CNS pathology in EAE and, potentially, multiple sclerosis. These findings may guide novel therapeutic approaches for multiple sclerosis and other neurologic diseases.#In an experimental autoimmune ...
These data provide key insights into astrocyte-specific contributions to AD, and we present this data set as a publicly available resource. 展开 关键词: Alzheimer's disease Posterior cingulate Astrocytes RNA sequencing Immune response Mitochondria ...
Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival. Top of pageMaterials and methods Results Discussion Acknowledgements References N-terminally truncated amyloid-β (Aβ) peptides are present in early and d... C Russo,E Violani,S Sal...
Though IL-9 was not significantly responsive to the specific AD-associated metabolites we tested, others found that higher neuron and astrocyte production of IL-9 in vitro is linked to AD progression79 and this is also observed in human studies80. Based on our findings, we hypothesize a ...
Then WGCNA::collapseRows was applied as above, and astrocyte-specific measurements (n = 8/22) were removed. 16,721 gene symbols shared between the expressed genes measured on Affymetrix and Agilent platforms were found and the corrected, normalized, log2-transformed expression values for each...
This pathogenesis is supported by pathology findings in AQP4+NMOSD showing: (1) antibody andcomplement deposition, (2) astrocyte damage or loss (even outside of lesioned tissue) with reducedAQP4expression, (3) granulocyte infiltration, and (4) secondary demyelination and axonal loss i...
Mitochondrial dysfunction has been implicated in the pathology of Parkinson’s disease (PD). In Dictyostelium discoideum, strains with mitochondrial dysfunction present consistent, AMPK-dependent phenotypes. This provides an opportunity to investigate if
Recently, some reports have suggested that SOX9 transcription factor (TF), an important mediator of astrocyte differentiation and maturation, might be linked to AD. Using human AD publicly available dataset, we aimed to analyze SOX9 expression and its relation to disease. Methodology: The AD gene ...
Astrocyte–neuron interactions in neurological disorders Meda, L., Baron, P., Scarlato, G.: Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins. Neurobiol. Aging 22(6)... G Ricci,L Volpi,L Pasquali,... - 《Journal of Biological Physics》 被引量: 164发...