The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-assoc
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Disease-associated astrocytes in Alzheimer’s disease and aging Nat. Neurosci., 23 (2020), pp. 701-706 CrossrefView in ScopusGoogle Scholar Haimon et al., 2018 Z. Haimon, A. Volaski, J. Orthgiess, S. Boura-Halfon, D. Varol, A. Shemer, S. Yona, B. Zuckerman, E. David, L. ...
141, 142 Astrocytes can also be a target for tau pathololgy, and specific expression of tau protein in astroglial cells can trigger age-dependent neurodegeneration.143, 144 Impairment of astroglia is also involved in pathogenesis of Wernicke encephalopathy, which is associated with a very ...
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targets for AD. Specifically, we develop a network-based ...
https://www.cellsignal.cn/pathways/astrocytes-in-neurodegeneration 星形胶质细胞是因其星形外观而得名的胶质细胞亚群,也是中枢神经系统 (CNS) 中最丰富的细胞类型。星形胶质细胞在脑中、尤其在血脑屏障处通过提供神经元维持和支持而发挥高度神经保护作用。星形胶质细胞还参与突触传递和神经炎症反应,并充当脑的载脂蛋...
Increased monoamine oxidase b activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography[J]. Neuroscience, 1994, 62(1): 15−30. DOI: 10.1016/0306−4522(94)90311−5. [8] Cosenza-Nashat M, Zhao ML, Suh HS, et al. Expression of the ...
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Disease-associated astrocytes in Alzheimer’s disease and aging. Nat. Neurosci. 23, 701–706 (2020). Article CAS Google Scholar Ioannou, M. S. et al. Neuron–astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell 177, 1522–1535 (2019). Article CAS Google ...
The high expression of SIRT1 and Beclin-1 (Atg6) is associated with shorter overall survival and reduced relapse-free survival in gastric cancer patients. In tumor gastric tumor samples, over 80% of malignant cells demonstrate increased autophagosome levels when compared to those of cells from ...