Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1鈥 8(EAE), an experimental model for multiple sclerosis. However, little is known about the stability of these astrocyte subsets and their ...
We identified an oligodendrocyte state that increased in association with brain pathology, which we termed disease-associated oligodendrocytes (DOLs). In a murine model of amyloidosis, DOLs appear long after plaque accumulation, and amyloid-beta (Aβ) alone was not sufficient to induce the DOL ...
Wischik Translational Neurodegeneration (2024) Aging-associated sensory decline and Alzheimer’s disease Suji Hong Seung-Hyun Baek Dong-Gyu Jo Molecular Neurodegeneration (2024)Sections Figures References Abstract Key points References Author information Ethics declarations Peer review Additional information ...
Although B2m signal was mainly associated with microglia (co-labeled using Tyrobp), B2m/Plp1 co-localization was strongly elevated in mice bearing amyloid pathology (Figures 3D–3F). We next examined the MOL-DA2 population using Cdkn1a as a marker. Because Plp1 was downregulated in the MOL-...
We applied bibliometric analytics to identify 300 highly cited papers relevant to Alzheimer's Disease research, published in the last 5 years. Members were invited to vote for their top 10 most influential papers of the last five years, and to comment on why they selected a particular article ...
Furthermore, since iPSCs can differentiate into various cell types associated with AD, they can better mimic GWAS-related diseases. CRISPR-based gene editing technology can introduce knockouts or single-nucleotide polymorphism (SNPs)-targeted mutations into iPSCs, thus providing a high-throughput ...
This study identified differential gene sets, common with two out of three AMP-AD cohorts (ROSMAP and MSBB) and highlights microglia and astrocyte as the key cell-types with DGEs associated with AD clinical diagnosis, and/or antemortem cognitive measure as well as neuropathological indices. Fut...
into 5-hmC, associated with late onset AD [86,166]. While the functional impact of changes in DNA hydroxymethylation associated with AD largely remain to be explored, the findings discussed in this section further support the notion of a widespread failure of the epigenetic regulatory system in ...
Associated content Role of oligodendrocytes in Aβ plaque burden Alexandra Le Bras Lab Animal Research Highlight 30 Aug 2024 Sections Figures References Abstract Main Methods Data availability Code availability References Acknowledgements Funding Author information Ethics declarations Peer review Additional ...
Astrocyte-derived interleukin 3 as a growth factor for microglia cells and peritoneal macrophages. J. Immunol. 137, 3521–3527 (1986). CAS PubMed Google Scholar Zambrano, A., Otth, C., Maccioni, R. B. & Concha, I. I. IL-3 controls tau modifications and protects cortical neurons ...