Activation-induced cytidine deaminase (AID) plays an essential role in the B-cell specific immunoglobulin (Ig) gene diversification reactions of class switch recombination (CSR), somatic hypermutation (SHM) and Ig gene conversion (GCV). It is generally believed that AID employs single-strand DNA ...
Activation induced cytidine deaminase (AID) plays a central role in the vertebrate adaptive immune response, initiating immunoglobulin (Ig) somatic hypermutation (SHM) and class-switch recombination (CSR). AID converts deoxycytosine (dC) in the DNA to deoxyuridine (dU), causing a DNA base-pairing...
Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins Activation-induced cytidine deminase (Aid), a unique enzyme that deaminates cytosine in DNA, shuttles between the nucleus and the cytoplasm. A recent study... A Yuko,W Akira,S Kuniaki,... - 《Plos ...
(iii) an activation-induced cytidine deaminase (AID)-related signature (signature 9). During B-cell development, AID induces deamination of cytosine to uracil. Resolution of these lesions by the error-prone DNA polymerase η (eta) results in A to C mutations at WA (W=A or T) motifs; ...
The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination of Ig genes. It has been shown that in vitro, AID protein deaminates C in single-stranded DNA or the coding-strand DNA that is being transcribed but not in double-stranded...
Activation-induced cytidine deaminase (AID), normally expressed in germinal centre activated B-cells, is an enzyme that edits DNA/RNA and induces somatic hypermutation and Ig class switching. AID expression is strictly controlled under physiological conditions; however, chronic inflammation and some ...
Activation-induced cytosine deaminase (AID) is a marker molecule produced by B cells to induce CSR of B cell immunoglobulin [41,42]. Monocytes and dendritic cells mainly secrete BAFF [43]. GBFXD treatment reduced the protein expression of BAFF, AID, and mRNA expression of APRIL, BAFFR, and...
In activated B cells, activation‐induced cytidine deaminase (AID) generates programmed DNA lesions required for antibody class switch recombination (CSR), which may also threaten genome integrity. AID dynamically shuttles between cytopl... X Xie,T Gan,B Rao,... - 《Embo Journal》 被引量: 0...
Replies to suggestions that yeast cytosine deaminase (CD) is a template for activation-induced cytidine deaminase (AID) structure prediction. Agreement that the elucidation of the structure of AID is essential for understanding the function of AID....
This unique recombination event involves formation of double-strand breaks (DSBs) in immunoglobulin switch (S) regions, and requires activation-induced cytidine deaminase (AID), which converts cytosines to uracils. Repair of the uracils is proposed to lead to DNA breaks required for recombination....