Activation-induced cytidine deaminase (AID) plays an essential role in the B-cell specific immunoglobulin (Ig) gene diversification reactions of class switch recombination (CSR), somatic hypermutation (SHM) and Ig gene conversion (GCV). It is generally believed that AID employs single-strand DNA ...
Activation-inducedcytidine deaminase(AID) plays a key role in both CSR and SHM.31, 40AID is a single-strand DNA (ssDNA) cytidine deaminase that can be expressed in activatedgerminal centerB cells. Transcription of animmunoglobulinV domain or of the switch region upstream of the CH1 domain ...
single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos UniProt Protein Name Single-stranded DNA cytosine deaminase UniProt Synonym Protein Names Activation-induced cytidine deaminase; Cytidine aminohydrolase ...
摘要: AICDA; AID; ARP2; CDA2 Activation-induced cytidine deaminase (AID) (EC 3.5.4.5) is a 198-amino acid polypeptide enzyme that is primarily expressed in germinal center (GC) B cells of the secondary...DOI: 10.1007/978-3-642-27841-9_7136-2 ...
Activation-induced cytidine deaminase (AID) is the mutator enzyme in adaptive immunity. AID initiates the antibody diversification processes in activated B cells by deaminating cytosine to uracil in immunoglobulin genes. To some extent other genes are also targeted, which may lead to genome instabilit...
Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in adult; 活化诱导胞嘧啶核苷脱氨酶基因多态性与成人哮喘及IgE的相关性研究 2) deoxycytidylate deaminase 脱氧胞嘧啶核苷酸脱氨酶 3) CD-TK 胞嘧啶脱氨酶-胸苷激酶 4) cytosine deaminase 胞嘧...
上海玉博生物科技有限公司 主要致力于“Anti-Human/Mouse Activation-Induced Cytidine Deaminase (MAID-2) Purified 14-5959-82”的生产销售。多年的“Anti-Human/Mouse Activation-Induced Cytidine Deaminase (MAID-2) Purified 14-5959-82”生产与销售的经验,与各行业
Activation-induced cytidine deaminase (AID) converts cytosines in S regions to uracils, which are excised by uracil DNA glycosylase (UNG). Repair of the resulting abasic sites would yield single-strand breaks (SSBs), but how these SSBs are converted to DSBs is unclear. In mouse splenic B...
By calculating the number of resistant clones, the mutation efficiency of each deaminase was estimated. From the analysis results (FIG. 3), it can be seen that the hsAID protein has the highest mutation efficiency. hsAID is a human-derived “Activation-induced cytosine deaminase” (AICDA, or...
(iii) an activation-induced cytidine deaminase (AID)-related signature (signature 9). During B-cell development, AID induces deamination of cytosine to uracil. Resolution of these lesions by the error-prone DNA polymerase η (eta) results in A to C mutations at WA (W=A or T) motifs; ...