当机体受到病原菌侵染后,外周免疫器官中的B细胞会大量表达胞苷脱氨酶基因AID(Activation-induced cytidine deaminase)。当AID结合到免疫球蛋白基因的可变区后会将单链DNA中的胞嘧啶脱氨化为尿嘧啶核苷,进而借助机体的损伤修复机制在可变区产生高频突变以筛选出具有高亲和力的抗体【1,2】。与此同时,AID会结合到免疫球...
Schreck S, Buettner M, Kremmer E, Bogdan M, Herbst H, Niedobitek G. Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours. J Pathol 2006; 210:26-31.
AID(活化诱导胞嘧啶脱氨酶, activation-induced cytidine deaminase)是一种抗体变异蛋白,之前被认为只能由成熟B细胞和转基因小鼠的发育中的B细胞产生。但是现在,Tufts大学的研究人员报道说,他们发现AID也能由野生型或正常的小鼠的发育中的B细胞产生。 生物通报道:AID(活化诱导胞嘧啶脱氨酶,activation-induced cytidine ...
(Activation-induced cytidine deaminase,AID, 亦称为 AICDA)基因为研究对象,检测其在牛卵母细胞及体外受精胚胎发育不同阶段的表达变化及其调节方式,揭示细胞重编程分子机 制.应用 Real-time PCR,BSP(Bisulfite Sequencing PCR)和免疫荧光化学等方法分析 DNA 甲基化对牛早期胚胎发育中 AID 基因表 达的影响.结果显示,...
AID (Activation induced cytidine deaminase) Monoclonal Antibody 供应商 Cayman Chemical 产品货号 32980-100 产品报价 ￥询价/100ul 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
适应性免疫系统采用多种抗体多样化策略提高抗体基因的多样性，包括核酸内切酶RAG介导的V(D)J重排以及胞苷脱氨酶AID（Activation-induced cytidine Deaminase）介导的体细胞高频突变（Somatic Hypermutation, SHM）、抗体类型转换（Class Switch Recombination, CSR）、抗体基因转换（Gene conversion, GCV）等。体细胞高频突变...
AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombinatio...
活化诱导的胞苷脱氨酶(activation-induced cytidine deaminase,AID亦称AICDA),为DNA/ RNA编辑酶,属于与诱变机制有关的APOBEC(apolipoprotein B mRNA editing catalytic polypeptide)蛋白家族。AID主要借助尿嘧啶-N-转葡萄糖基酶将单链DNA的胞嘧啶(C)脱氨基而转换为尿嘧啶(U),在免疫球蛋白基因的类别转换(CS R)和体细...
背景资料Activation-induced cytidine deaminase,also known as AICDA and AID,is a 24kDa enzyme which in humans is encoded by the AICDA gene.This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family.The protein is involved in somatic hypermutation,gene conversion,an...
Activation-induced cytidine deaminase (AID) is the mutator enzyme in adaptive immunity. AID initiates the antibody diversification processes in activated B cells by deaminating cytosine to uracil in immunoglobulin genes. To some extent other genes are also targeted, which may lead to genome instabilit...