The invention also provides cytidine deaminase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an cytidine deaminase-like gene has ...
专利名称：26934, A NOVEL CYTIDINE DEAMINASE-LIKE MOLECULE AND USES THEREOF 发明人：MEYERS, Rachel, E.,RUDOLPH-OWEN, Laura 申请号：US2001007783 申请日：20010309 公开号：WO01/068806P1 公开日：20010920 专利内容由知识产权出版社提供 摘要：Novel cytidine deaminase-like polypeptides, proteins, and nucleic...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook (redirected fromCytidine deaminase) Thesaurus Medical Encyclopedia de·am·i·nate (dē-ăm′ə-nāt′) tr.v.de·am·i·nat·ed,de·am·i·nat·ing,de·am·i·nates ...
Cytidine DeaminaseProtein BindingProtein TransportMutationDiffusionHIV-1Models, BiologicalDeamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The ...
APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G) was identified as an anti- HIV-1 (human immunodeficiency virus type 1) cellular factor in target CD4 T cells. It is a member of the APOBEC family of cytidine deaminases consisting of APOBEC1, APOBEC2, APOBEC3 (A...
Activation Induced Cytidine DeaminaseA number of transcriptional, posttranscriptional and posttranslational mechanisms are known to regulate AID expression and function. Here we first overview the signaling pathways leading to AID expression in B cells , which mostly respond to surface receptors that ...
In addition to isolated, full-length cytidine deaminase-like proteins, the invention furt... RA Meyers,LA Rudolphowen 被引量: 3发表: 2004年 BASE EDITORS AND USES THEREOF Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted ...
Cytidine Deaminase in Myeloprotective Gene Therapy NicoLachmann, ...ThomasMoritz, inGene Therapy of Cancer (Third Edition), 2014 Cytidine Deaminase: Structure, Function, and Role in Therapy with Cytidine Analog CDD(EC 3.5.4.5.) is anenzymeinvolved in thenucleotide salvagepathway and catalyzes the...
The activationinduced cytidine deaminase (AID)/apolipoprotein B mRNA editing enzyme, catalytic polypeptidelike (APOBEC) family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. It is important...
deaminase 3D structure is fundamentally linked to its functional properties, so we characterized the function (C-to-T editing activity) of representative deaminases from each cluster. Only the active domain of APOBEC-like deaminase was used as the basis for identifying candidate homologue deaminases ...