引言：CDA（chondroitinase ABC-derived protein, C-ABC-derived protein）重组蛋白是一种新型生物学蛋白质，来源于chondroitinase ABC（C-ABC），具有广泛的生物学功能和应用潜力。在本文中，我们将全面介绍CDA重组蛋白的物理化学性质、生物学功能和在生物学研究、医学临床等领域的应用情况。目录号 PA1000-8027一、CDA重...
Xu, Q, Kozbial, P, McMullan, D (2008) Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution. Proteins 71: pp. 1546-1552...
Twitter Google Share on Facebook (redirected fromCytidine deaminase) Thesaurus Medical Encyclopedia de·am·i·nate (dē-ăm′ə-nāt′) tr.v.de·am·i·nat·ed,de·am·i·nat·ing,de·am·i·nates To remove an amino group, NH2, from (an organic compound). ...
Here, to define the cancer cell response to gemcitabine, we performed genome-scale CRISPR–Cas9 chemical–genetic screens in PDAC cells and found selective loss of cell fitness upon disruption of the cytidine deaminases APOBEC3C and APOBEC3D. Following gemcitabine treatment, APOBEC3C and APOBEC3D ...
APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G) was identified as an anti- HIV-1 (human immunodeficiency virus type 1) cellular factor in target CD4 T cells. It is a member of the APOBEC family of cytidine deaminases consisting of APOBEC1, APOBEC2, APOBEC3 (A...
Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found applicatio
Cytidine Deaminase: Structure, Function, and Role in Therapy with Cytidine Analog CDD(EC 3.5.4.5.) is anenzymeinvolved in thenucleotide salvagepathway and catalyzes thedeaminationofcytidineanddeoxycytidinetouridineanddeoxyuridine, respectively (Figure 29.1B.1). The CDD gene is located on the small arm...
Deaminase,cytidinecas:9025-06-3 r-Cytidinecas:13913-16-1 1. Names and Identifiers 2. Properties 3. Use and Manufacturing 4. Safety and Handling 5. Msds 6. NMR Spectrum 7. Synthesis Route 8. Precursor and Product 9. Computational chemical data 10. Other Information 11. Toltal 324 Supplie...
AID activation-induced cytidine deaminase CB Cajal body CTNNBL1 catenin-β-like protein 1 CSR class switch recombination Fib fibrillarin LeptB leptomycin B NLS nuclear localization signal SC35 35 kD serine/arginine-rich splicing factor 2 SHM somatic hypermutation SMN survival of motor neuron Sm protei...
Activation Induced Cytidine DeaminaseA number of transcriptional, posttranscriptional and posttranslational mechanisms are known to regulate AID expression and function. Here we first overview the signaling pathways leading to AID expression in B cells , which mostly respond to surface receptors that ...