A major breakthrough came in 2000 with the discovery that activation-induced deaminase (AID) is absolutely required for hypermutation. This was followed in 2002 by evidence that AID directly edits the DNA that encodes an antibody in an activated B cell. Much has since been learnt about the ...
Yet both depend on activation-induced deaminase (AID), the function of which in the two reactions has been an enigma. Here we report that B cell stimulation which induces CSR but not SHM, leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region, uncoupled ...
Activation-induced deaminase (AID) is required for three distinct reactions crucial to the diversification of the antibody repertoire; these are somatic hypermutation (SHM), class switch recombination (CSR) and gene conversion (GC). AID is a cytidine deaminase and is believed to initiate these react...
A major breakthrough came in 2000 with the discovery that activation-induced deaminase (AID) is absolutely required for hypermutation. This was followed in 2002 by evidence that AID directly edits the DNA that encodes an antibody in an activated B cell. Much has since been learnt about the ...
Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways. A role for AID at the repair step is unclear. We show that specific inactivation of the C-terminal AID...
Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region segments, three processes that diversify antibodies during immune responses. Although AID has ...
activation-induced cytidine deaminase expression 是活化诱导胞嘧啶核苷脱氨酶的表达的意思
Activation-inducedcytidine deaminase(AID) plays a key role in both CSR and SHM.31, 40AID is a single-strand DNA (ssDNA) cytidine deaminase that can be expressed in activatedgerminal centerB cells. Transcription of animmunoglobulinV domain or of the switch region upstream of the CH1 domain ...
www.nature.com/scientificreports OPEN received: 01 July 2016 accepted: 07 November 2016 Published: 07 December 2016 Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers Igor B. Rogozin1,2, Artem G. Lada3,4, Alexander...
Activation-induced cytidine deaminase (AID) is critically involved in class switch recombination and somatic hypermutation of Ig loci resulting in diversification of antibodies repertoire and production of high-affinity antibodies and as such represents a physiological tool to introduce DNA alterations. These...