Unlike bulky base adducts induced by UV and other environmental mutagens in the genome that block replicative DNA polymerases, oxidatively damaged bases such as 5-hydroxyuracil, produced by oxidative deamination of cytosine in the template strand, do not block replicative polymerases and thus need to...
In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this featu
indicating changes in the phosphate asymmetric stretching of the DNA backbone. No significant shift was observed in the region corresponding to cytosine ring vibrations, 1493 cm-1to 1492 cm-1. The absorption signal at 1713 cm-1shifted to 1709 cm-1in the 4-Cl-OPD-DNA, signifying slight vibrat...
the cytosine, and thymine form 5-hydroxy or 4,5-dihydroxy product, e.g. thymine glycol. Also, a very common somatic mutation is found among guanosine and thymidine, achieved by the hydroxylation of guanosine at the eighth position, which further goes to keto-enol tautomerism, mimicking the ...
but an enhancement of ROS production or lack of antioxidant production results in oxidative stress and may cause DNA double-strand break (Waris and Ahsan2006). ROS can cause transition mutation in DNA because it induces deamination of cytosine to uracil or 5-hydroxyuracil, and during DNA replicat...
Unlike bulky base adducts induced by UV and other environmental mutagens in the genome that block replicative DNA polymerases, oxidatively damaged bases such as 5-hydoxyuracil (5-OHU), produced by oxidative deamination of cytosine in the template strand, do not block replicative polymerases and ...
2. From nitrates, nitrites and nitrosamines in organism is formed nitrous acid which causes oxidative deamination of nitrogene bases of nucleotides. This induce a point mutation by replacement of cytosine to...E. Reversal translation
(Fig.3dand Extended Data Fig.6), an age-related, ‘clock-like’ signature previously observed in many cancers26, normal cycling cells6and single neurons5. This signature has been proposed to reflect faulty repair of deamination of methylated cytosines to thymine that frequently occurs in the ...
levels have been successfully restored. Alternatively, it has been proposed that RAGs are activated by glutamine, specifically byα-ketoglutarate generated upon double deamination occurring in the glutaminolytic pathway.26Although mTOR activation through this mechanism needs to be still clarified, it ...
levels have been successfully restored. Alternatively, it has been proposed that RAGs are activated by glutamine, specifically byα-ketoglutarate generated upon double deamination occurring in the glutaminolytic pathway.26Although mTOR activation through this mechanism needs to be still clarified, it ...