Define deamination. deamination synonyms, deamination pronunciation, deamination translation, English dictionary definition of deamination. tr.v. de·am·i·nat·ed , de·am·i·nat·ing , de·am·i·nates To remove an amino group, NH2, from . de·am′i
3.The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. 4.Some looked more ‘ancient’ than others, showing abundant deamination at the ends of DNA fragments. ...
Cytosine deamination produces mismatched uracil (U), which can be removed by uracil glycosylase , whereas m~5C deamination generates a G T mispair that cannot be processed by this enzyme. Correction of m~5CpG路TpG mismatches may instead be initiated by the thymine DNA glycosylase, TDG. Here ...
The APOBEC3 family of cytosine deaminase enzymes are able to restrict replication of retroelements, such as LINE-1. However, each of the seven APOBEC3 enzymes have been reported to act differentially to prevent LINE-1 retrotransposition and the mechanisms of APOBEC3-mediated LINE-1 inhibition has...
Nandy P, Periclou A, Avramis V (1997) The synergism of 6-mercaptopurine plus cytosine arabinoside followed by PEG-asparaginase in human leukemia cell lines (CCRF/CEM/0 and (CCRF/CEM/ara-C/7A) is due to increased cellular apoptosis. Anticancer Res 18:727–737 Google Scholar Ngan C-H, ...