Ehrlich M, Zhang X-Y, Inamdar NM (1990) Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutation Res 238:277–286Ehrlich M, Zhang XY, Inamdar NM (1990) Spontaneous deamination of cytosine and 5-...
M. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutat. Res. 238(3), 277–286 (1990). 4. Kunz, C., Saito, Y. & Schar, P. DNA Repair in mammalian cells: Mismatched repair: Variations on a ...
It is unknown how the composition and structure of DNA within the cell affect spontaneous mutations. Theory suggests that in eukaryotic genomes, nucleosomal DNA undergoes fewer C→T mutations because of suppressed cytosine hydrolytic deamination relative to nucleosome-depleted DNA. Comparative genomic analy...
The potential effect of spontaneous post-mortem deamination of cytosine residues on the resolution of methylation patterns.Bastien, LlamasMichelle, L. HollandKefei, ChenJennifer, E. CropleyAlan, CooperCatherine, M. Suter
deamination of cytosine c. tautomeric shift in adenine d. tautomeric shift in thymine e. all of the above Which of the following mutations would you expect to have the greatest effect on a living cell? A. mutation that changes a...
1990). The proposed mechanism involves 5-methylation of cytosine by a methyltransferase and spontaneous deamination of 5-methylcytosine to thymine. This type of mutation was observed in 10 of the 12 families in this report (or in 13 of the 18 RTT families total). C→T or G→A (when the...
It is unknown how the composition and structure of DNA within the cell affect spontaneous mutations. Theory suggests that in eukaryotic genomes, nucleosomal DNA undergoes fewer C -> T mutations because of suppressed cytosine hydrolytic deamination rel
(known as non-canonical or non-Watson–Crick base pair)1either endogenously during the biological processes like DNA replication2, recombination, spontaneous deamination, etc.3,4,5or exogenously by ionizing radiations such as X-rays and gamma rays2,6, and by the action of certain chemical ...
administration of GS-9219 as monotherapy.In lymphocytes, GS-9219 is converted to its active metabolite, PMEG diphosphate, via enzymatic hydrolysis, deamination, and phosphorylation. GS-9219 has substantial antiproliferative activity against activated lymphocytes and hematopoietic tumor cell lines. In ...
These base changes swap cytosine and thymine, most likely as the result of the spontaneous deamination of methylated cytosine. One of these base changes causes an amino-acid change in the protein: normal threonine at position 239 is changed to isoleucine. This position is close to the site of...