Activation-induced cytidine deaminase (AID) plays an essential role in the B-cell specific immunoglobulin (Ig) gene diversification reactions of class switch recombination (CSR), somatic hypermutation (SHM) and Ig gene conversion (GCV). It is generally believed that AID employs single-strand DNA ...
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Activation-inducedcytidine deaminase(AID) plays a key role in both CSR and SHM.31, 40AID is a single-strand DNA (ssDNA) cytidine deaminase that can be expressed in activatedgerminal centerB cells. Transcription of animmunoglobulinV domain or of the switch region upstream of the CH1 domain ...
Activation-induced cytidine deaminase (AID) is critically involved in class switch recombination and somatic hypermutation of Ig loci resulting in diversification of antibodies repertoire and production of high-affinity antibodies and as such represents a physiological tool to introduce DNA alterations. These...
Activation-induced cytidine deaminase (AID) is the mutator enzyme in adaptive immunity. AID initiates the antibody diversification processes in activated B cells by deaminating cytosine to uracil in immunoglobulin genes. To some extent other genes are also targeted, which may lead to genome instabilit...
Activation-induced cytidine deaminase (AID), a protein necessary for somatic hypermutation and class switch recombination, is expressed in the germinal center (10) and in extrafollicular large proliferating B cells. Activation-induced cytidine deaminase was coexpressed in 4 of 4 cases tested (Figure ...
Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4+ T cells that had expressed Aicda (exAID cells) as well as B cells. Ex...
Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and changing affinity. This is possible through its DNA deamin...
AID; ARP2; CDA2; HIGM2; HEL-S-284 [Similar Products] NCBI Protein Information single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos UniProt Protein Name ...
Activation-induced cytidine deaminase (AID) is the only enzyme that has been suggested as a putative DNA demethylase in mammals. However, very little is known about AID function as DNA demethylase of bovine differentiated cells toward pluripotent state. To investigate the effect of AID on DNA deme...