Genetic TestingGenome, HumanGenome-Wide Association StudyGenetic Predisposition to DiseaseQuality ControlExtraordinary technological advances and decreases in the cost of DNA sequencing have made the possibility of whole genome sequencing (WGS) as a highly accessible clinical test for numer...
The first large-scale study demonstrating how phenotypic testing can be replaced by WGS for first-line drug testing. Google Scholar Gardy, J. L. et al. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N. Engl. J. Med. 364, 730–739 (2011). CAS PubMed ...
Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites wh
Testing gene-environment interaction in PD using whole-genome sequencing (WGS) of pesticide-exposed cohorts 来自 dx.doi.org 喜欢 0 阅读量: 9 作者:S Goldman,J Kaye,M Traglia,R Swanson,L Lima,S Finkbeiner,C Tanner DOI: 10.1016/j.parkreldis.2024.106116 年份: 2024 ...
Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in TB drug-resistance surveillance and...
we performed in-depth analysis of 24 equineActinobacillusisolates using phenotypic identification and susceptibility testing on the one hand, and long-read nanopore whole genome sequencing on the other hand. This allowed to address strain divergence down to the whole genome single nucleotide polymorphism...
Genome Biol. 2014;15:550. Article PubMed PubMed Central Google Scholar Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Ser B-Stat Methodol. 1995;57:289–300. Google Scholar Yu J, Zhou Y, Tanaka I, ...
Objectives: The objectives of this study were to identify antimicrobial resistance genotypes for Campylobacter and to evaluate the correlation between resistance phenotypes and genotypes using in vitro antimicrobial susceptibility testing and whole-genome sequencing (WGS). Methods: One hundred-fourteen Campylob...
Figure 1. Next generation sequencing approaches.NGS can be applied for different uses, including (A) whole exome sequencing (WES), where sequencing reads are focused on protein-coding regions of the genome; and (B) whole genome sequencing, where both coding and non-coding DNA regions are anal...
Whole-genome sequencing (WGS) is becoming an increasingly important tool for detecting genomic variation. Blood derived DNA is the current standard for WGS for research or clinical purposes but may not always be feasible to acquire. The usability of DNA