Drug resistance in cancer: principles of emergence and prevention. Proc. Natl Acad. Sci. USA 102, 9714–9719 (2005). Article CAS PubMed PubMed Central Google Scholar Durrett, R. & Moseley, S. Evolution of resistance and progression to disease during clonal expansion of cancer. Theor. ...
ResponseProduction and Clonal Expansion in a Th1 g Induction in Postdifferentiation IFN-B k T Cell-Intrinsic Requirement for NF-Mark NF- (cid:1) B/Rel transcription factors are linked to innate immune responses and APC activation. Whether and how the induction of NF- (cid:1) B signaling ....
The homeostasis of normal tissues is a balance between cell proliferation and cell death. Alterations of both pathways contribute to a clonal expansion of cancer cells. Bcl-2 and its family play an important role in the regulation of the apoptotic pathway. Apoptosis or programmed cell death is ...
Over the past decade, cancer stem cells have emerged as the centerpiece of cancer research, having a major role in resistance to conventional therapy and in the metastatic spread of tumours. The authors discuss the biological complexity of this subpopula
MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology. 1988;38180- 185Google ScholarCrossref 59. Fazekas FOffenbacher HFuchs S et al. Criteria for an increased specificity of MRI interpretation in ...
It will be argued that this multistage, multimechanism model of carcinogenesis, involving the “initiation” of a single cell by a mutagen event, followed by chronic exposure to threshold levels of epigenetic agents or conditions that stimulate the clonal expansion of the �...
To address this limitation, recombinant oligoclonal antibodies (mixtures of recombinant monoclonals) are being developed. Primary and secondary antibodies The main difference between primary and secondary antibodies is the types of biomolecules that they recognize and bind. While primary antibodies recognize...
As spleen cells have limited survival times in culture, they require fusion with myelomas, cancerous B-Cells, to create an immortalized hybrid that can undergo many passagesin vitro. This is achieved through polyethylene glycol (PEG) or electric pulses both of which disrupt cell membrane and all...
their prevalence in human populations is changing, often to an extreme degree. In this Essay, we propose that the disappearance of these ancestral indigenous organisms, which are intimately involved in human physiology, is not entirely beneficial and has consequences that might include post-modern con...
Comparing pure clonal brown and beige cells, it appears that the classical brown fat cells have a higher basal UCP1 expression and elevated uncoupled respiration (relative to white or beige cells) before hormonal stimulation. Beige cells, on the other hand, have low basal UCP1 expression and ...