Greaves, M., Maley, C. Clonal evolution in cancer.Nature481, 306–313 (2012). https://doi.org/10.1038/nature10762 Download citation Published18 January 2012 Issue Date19 January 2012 DOIhttps://doi.org/10.1038/nature10762 Subjects Cancer genomics ...
Clonal evolution in cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite for Darwinian selection at the micro-level. It has been frequently suggested in the literature that clonal evolution can be promoted by an elevated rate of mutation in ...
Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and ...
Carlos Caldas is in the Department of Oncology at the University of Cambridge and at Cancer Research UK, Cambridge Research Institute, Cambridge, UK., Carlos Caldas Corresponding author Correspondence to Carlos Caldas. Ethics declarations Competing interests The author declares no competing financial int...
Clonal evolutionin cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite forDarwinian selectionat the micro-level. It has been frequently suggested in the literature thatclonal evolutioncan be promoted by an elevated rate of mutation in tumor ce...
Cancer Stem Cells and Glioblastoma Shackleton M, Quintana E, Fearon ER, Morrison SJ (2009) Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138:822–829 Sheiness... P Hamerlik - Springer Vienna 被引量: 5发表: 2014年 Onset of heterogeneity in culture-expanded bone mar...
To elucidate the mechanisms driving the evolution of high-grade glioma under therapy, we analyzed 293 whole exomes and 141 transcriptomes from longitudinal tumor–matched normal samples in 114 patients with GBM (Fig. 1a). Patients with recurrent GBM (89 diagnosed with primary GBM) were collected ...
Cancer stem cells: A product of clonal evolution? The cancer stem cell (CSC) model has emerged as a Davids,M Lester,V Niekerk,... - International Journal of Cancer =: Journal International du Cancer 被引量: 7发表: 2017年 Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, ...
Development and Application of Single-Cell Technologies to Study Clonal Evolution in Human Hematopoiesis Molecular biology.Medicine.Genetics.The evolutionary history of cancer begins with the acquisition of somatic mutations that lead to clonal outgrowths. As clones grow, they further undergo genetic ...
C. Clonal evolution in cancer. Nature 481, 306–313 (2012). CAS PubMed PubMed Central Google Scholar Williams, M. J., Werner, B., Graham, T. A. & Sottoriva, A. Functional versus non-functional intratumor heterogeneity in cancer. Mol. Cell. Oncol. 3, e1162897 (2016). PubMed Pub...