Greaves, M., Maley, C. Clonal evolution in cancer.Nature481, 306–313 (2012). https://doi.org/10.1038/nature10762 Download citation Published18 January 2012 Issue Date19 January 2012 DOIhttps://doi.org/10.1038/nature10762 Subjects Cancer genomics ...
This dissertation considers some of the implications of clonal evolution in cancer with an emphasis on how the evolutionary process, itself, facilitates disease progression and how its signature can be clinically used for early disease detection. The first part introduces the subject of mutations in ...
Clonal evolutionin cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite forDarwinian selectionat the micro-level. It has been frequently suggested in the literature thatclonal evolutioncan be promoted by an elevated rate of mutation in tumor ce...
Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and ...
Here we review the prevalence of clonal hematopoiesis in the cancer setting. We explore its impact on cancer-related survival, potential underlying mechanisms, how genotoxic stressors contribute to malignant clonal evolution, and how we might use clonal hematopoiesis to inform future opportunities for ...
Cancer stem cells: A product of clonal evolution? The cancer stem cell (CSC) model has emerged as a Davids,M Lester,V Niekerk,... - International Journal of Cancer =: Journal International du Cancer 被引量: 7发表: 2017年 Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, ...
Carlos Caldas is in the Department of Oncology at the University of Cambridge and at Cancer Research UK, Cambridge Research Institute, Cambridge, UK., Carlos Caldas Corresponding author Correspondence to Carlos Caldas. Ethics declarations Competing interests The author declares no competing financial int...
Cancer Clonal Evolution and Intra-tumor Heterogeneity Indeed, most of cancers shows usually a single clonal origin at the early stages of the disease, but, in advanced stages, tumors may include multiple cell populations with different properties. A key event in cancer clonal evolution ... D Fan...
Cancer evolution: mathematical models and computational inference. Syst. Biol. 64, e1–25 (2015). Article CAS Google Scholar Greaves, M. & Maley, C.C. Clonal evolution in cancer. Nature 481, 306–313 (2012). Article CAS Google Scholar Nowell, P.C. The clonal evolution of tumor cell...
C. Clonal evolution in cancer. Nature 481, 306–313 (2012). CAS PubMed PubMed Central Google Scholar Williams, M. J., Werner, B., Graham, T. A. & Sottoriva, A. Functional versus non-functional intratumor heterogeneity in cancer. Mol. Cell. Oncol. 3, e1162897 (2016). PubMed Pub...