Big Bang Tumor Growth and Clonal Evolutiondoi:10.1101/CSHPERSPECT.A028381Ruping SunZheng HuChristina CurtisCold Spring Harbor Laboratory Press
Here we present and validate a 'Big Bang' model, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public (clonal) and most detectable private (subclonal) alterations arise early during growth. ...
These mutations were clustered and occupied major population across multi-lesional tumor samples. Our data suggested their lung cancers progressed with punctuated and big bang evolutional model. Conclusion: We should pay attention to clinical course of lung cancer patients harboring multiple clonal driver...