We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non...
According to the clonal evolution model of cancer, intra-tumour heterogeneity creates the conditions for inter-clonal competition and selection, which could result in selective sweeps and a general reduction in levels of heterogeneity [4]. However, it has been suggested that in addition to competing...
Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the ...
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wou...
Cancer stem cells: A product of clonal evolution? The cancer stem cell (CSC) model has emerged as a prominent paradigm for explaining tumour heterogeneity. CSCs in tumour recurrence and drug resistance hav... G Van Niekerk,LM Davids,SM Hattingh,... - 《International Journal of Cancer》 被引...
AlexanderPietras, inAdvances in Cancer Research, 2011 AThe Clonal Evolution Model As first proposed byNowell (1976), theclonal evolutionmodel for tumor progression suggests that within a population of tumor cells, anatural selectionoccurs that favors cells that have acquired (e.g., through additiona...
Among tumors, melanoma and non-small cell lung cancer (NSCLC) can provide an interesting example of intra-tumor heterogeneity. In this chapter, we will describe the model of cancer clonal evolution and concept of intra-tumor heterogeneity, discussing how these may affect the tumor recurrence, ...
The identification of the pattern in cancer clonal evolution and the driver events that conferred selective advantages in tumor progression is of clinical importance. Applying single-cell sequencing techniques can dissect tumors at the cellular level, further revealing the pathogenesis and clonal evolution...
The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor’s immunological phenotype. However, there i
analysis.Along with the identification of cancer stem cells in the majority of neoplasia, the recognition of intertumor and intratumor variability has provided a novel perspective to understand the mechanisms behind tumor evolution and its implication in terms of treatment failure and cancer relapseor ...