We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non...
Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the ...
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wou...
According to the clonal evolution model of cancer, intra-tumour heterogeneity creates the conditions for inter-clonal competition and selection, which could result in selective sweeps and a general reduction in levels of heterogeneity [4]. However, it has been suggested that in addition to competing...
Cancer Stem Cells in Tumor Heterogeneity AThe Clonal Evolution Model As first proposed byNowell (1976), theclonal evolutionmodel for tumor progression suggests that within a population of tumor cells, anatural selectionoccurs that favors cells that have acquired (e.g., through additional mutations) ...
Additionally, there remain many challenges in transforming the observational studies of rich heterogeneous cell-state phenomenology from single-cell analysis to a mechanical understanding of cancer evolution dynamics and causal mechanism patterns [19]. For example, defining a common feature to reflect the...
Tumor evolution begins when individual cells in normal tissue transform and expand to form a tumor mass. In this complex biological process, clonal lineages differentiate and form distinct subpopulations, resulting in intra-tumor heterogeneity (ITH)[15]. The genesis of cancer intricately intertwines ...
Spatiotemporal evolution of the primary glioblastoma genome. Cancer Cell 28, 318–328 (2015). Article CAS PubMed Google Scholar Kim, H. et al. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 25, 316–...
The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor’s immunological phenotype. However, there i
Department of Surgery, Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center, University of California, 2340 Sutter Street PO Box 1351, San Francisco, 94115, California, USA Carlo C. Maley Corresponding author Correspondence toMel Greaves. ...