We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non...
Christoph A.Klein - 《European Journal of Cancer》 被引量: 194发表: 2013年 Advances for studying clonal evolution in cancer The "clonal evolution" model of cancer emerged and "evolved" amid ongoing advances in technology, especially in recent years during which next generation s... L Ding,BJ...
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wou...
Among tumors, melanoma and non-small cell lung cancer (NSCLC) can provide an interesting example of intra-tumor heterogeneity. In this chapter, we will describe the model of cancer clonal evolution and concept of intra-tumor heterogeneity, discussing how these may affect the tumor recurrence, ...
Department of Surgery, Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center, University of California, 2340 Sutter Street PO Box 1351, San Francisco, 94115, California, USA Carlo C. Maley Corresponding author Correspondence toMel Greaves. ...
While direct evidence for any model of tumor progression is difficult to come by, the clonal evolution hypothesis is compatible with several characteristics of cancer including phenotypic heterogeneity (Marusyk and Polyak, 2009), genetic instability (Hanahan and Weinberg, 2000), and the frequent emerge...
We used our established in vivo chemical carcinogenesis model of head and neck cancer to characterize dormant micrometastatic disease using genetic lineage tracing and null mutant mice. Histopathology was analyzed by hematoxylin and eosin staining. Telomere DNA damage response was determined by immuno...
The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor’s immunological phenotype. However, there i
Targeted Disruption of FANCC and FANCG in Human Cancer Provides a Preclinical Model for Specific Therapeutic Options Background & Aims: How specifically to treat pancreatic and other cancers harboring Fanconi anemia gene mutations has raised great interest recently, yet p... E Gallmeier,ES Calhoun...
Abstract. Development of cancer requires the acquisition of multiple oncogenic mutations and selection of the malignant clone. Cancer evolves within a fini