Clonal origin of bladder cancer. N Engl J Med. 1992;326:737-740.Sydransky D,Frost F,Von Eschenbach A,et al.Clonal origin of bladder cancer[ J].N Engl J Med,1992,326:737 ～740.Sidransky D, Frost P,Eschenbach AV, Oyasu R, Preisinger AC, Vogelstein B. Clonal origin of bladder ...
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung ...
Clinical implications of multicentric origin. Cancer 6, 963–968 (1953). Article CAS PubMed Google Scholar Braakhuis, B. J. M., Tabor, M. P., Kummer, J. A., Leemans, C. R. & Brakenhoff, R. H. A genetic explanation of Slaughter's concept of field cancerization: evidence and ...
Cancer Clonal Evolution and Intra-tumor Heterogeneity Indeed, most of cancers shows usually a single clonal origin at the early stages of the disease, but, in advanced stages, tumors may include multiple cell populations with different properties. A key event in cancer clonal evolution ... D Fan...
The clonal evolution hypothesis is based on the idea that most cancers arise from a single altered cell, and every cell within a tumor is equally likely to be the cell of origin. From:Trends in Cancer,2015 About this page Set alert ...
Clonal hematopoiesis in the cancer setting Research into clonal hematopoiesis and our understanding of its scope has grown significantly over the past 5 years since interest in this phenomenon was rekindled. We know clonal hematopoiesis represents a highly prevalent, age-related premalignant condition and...
Indeed, most of cancers shows usually a single clonal origin at the early stages of the disease, but, in advanced stages, tumors may include multiple cell populations with different properties. A key event in cancer clonal evolution process is the variability observed within individual tumors, ...
1.To make multiple identical copies of (a DNA sequence). 2.To create or propagate (an organism) from a clone cell:clone a sheep. 3.To reproduce or propagate asexually:clone a plant variety. 4.To produce a copy of; imitate closely:"The look has been cloned into cliché"(Cathleen McGu...
Cell Reports Resource High-Definition Reconstruction of Clonal Composition in Cancer Andrej Fischer,1,* Ignacio Va´ zquez-Garcı´a,1,2 Christopher J.R. Illingworth,3 and Ville Mustonen1,* 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge...
First, evidence for the monoclonal origin of fibrous-capped plaques was provided by the findings that small plaques had G-6-PD isoenzyme distributions similar to those of leimyomas; that in large plaques with multiple portions assayed for G-6-PD, a large proportion (25 of 26, 96%) of ...