Clonal origins of bladder cancer. N. Engl. J. Med., 326: 737a€"740, 1992.Sidransky D et al.Clonal origin of bladder cancer. The New England Journal of Medicine . 1992Sidransky EA, Frost P, von Eschenbach A, et al. Clonal origin of bladder cancer. N Engl J Med. 1992;326:737...
Regulatory CD4+T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patient...
The molecular basis of common and rare fragile sites. Cancer Lett. 232, 13–26 (2006). CAS PubMed Google Scholar Loeb, L. A. Human cancers express mutator phenotypes: origin, consequences and targeting. Nature Rev. Cancer 11, 450–457 (2011). CAS Google Scholar Weisenberger, D. J. ...
In this article, we review the origin and therapeutic perspectives of bladder cancer stem cells (BCSCs), which are integral to the initiation, high recurrence and chemoresistance of bladder cancer. BCSCs are heterogenous and originate from multiple cell types, including urothelial stem cells and dif...
Indeed, most of cancers shows usually a single clonal origin at the early stages of the disease, but, in advanced stages, tumors may include multiple cell populations with different properties. A key event in cancer clonal evolution process is the variability observed within individual tumors, ...
A cancer is considered monoclonal when all cells within the tumor can be traced back to a single progenitor/initiator cell. Instead, a polyclonal malignancy derives from the concomitant transformation of two or more different ancestor cells. Determining the clonal status of a cancer can be quite ...
The clonal evolution hypothesis is based on the idea that most cancers arise from a single altered cell, and every cell within a tumor is equally likely to be the cell of origin. From: Trends in Cancer, 2015 About this pageAdd to MendeleySet alert ...
From a bone developmental perspective, mesenchymal-derived osteoprogenitor cells arise/reside in the periosteal tissue or the bone marrow stroma. The marrow and its stromal “bedding” give rise to multipotential cells of both hematopoietic lineage (origin of osteoclasts) and nonhematopoietic lineage cel...
oncogenic KRAS-driven genetically-engineered mouse models that phenotypically and genetically recapitulate human pancreatic cancer have clarified the mechanisms through which various mutated genes act in neoplasia induction and progression and have led to identifying the possible cellular origin of these neoplas...
1.To make multiple identical copies of (a DNA sequence). 2.To create or propagate (an organism) from a clone cell:clone a sheep. 3.To reproduce or propagate asexually:clone a plant variety. 4.To produce a copy of; imitate closely:"The look has been cloned into cliché"(Cathleen McGu...