Cancer bioenergeticsBiological coherenceMicrotubulesA growing number of inconsistencies have accumulated within the genetically deterministic paradigm of the origin of cancer. Among them the most important are the nonspecific nature of cancer mutations and the non-cell-autonomous factors of cancer initiation ...
The origin of cancer cell in human uterine carcinoma was investigated, mainly, on the ordinary sectioned materials stained with haematoxylin and eosin. The results obtained are described as follows (i) The new cell theory, presented by O. B. Lepeshinskaya and O. P. Lepeshinskaya is true, ...
In each major theory of the origin of cancer—field theory, chemical carcinogenesis, infection, mutation, or epigenetic change—the tissue stem cell is involved in the generation of cancer. Although the cancer type is identified by the more highly differentiated cells in the cancer cell lineage ...
Anderberg C, Pietras K (2009) On the origin of cancer-associated fibroblasts. Cell Cycle 8:1561-1465Anderberg, C., and Pietras, K. (2009). On the origin of cancer-associated fibroblasts. Cell Cycle 8, 1461- 1462.Anderberg C, Pietras K. On the origin of cancer-associated fibroblasts....
Detached cancer cells gather together to cause the hypoxic environment that promotes HIF1α mediated mitophagy, removing damaged mitochondria, supporting glycolysis, which promotes cancer cell progression. Disruption of metabolic adaptation or cell clusters leads to a decline of the metastatic ability of ...
CA4P also disrupts endothelial cell-to-cell VE-cadherin junctions13 and within minutes the permeability of monolayers rises through processes that are Rho/ROCK dependent8. The effects of CA4P on endothelial morphology and permeability are postulated to contribute to tumour vascular collapse, which ...
Promotion-progression to cancer from radiation initiated clonogens has, however, been shown to be inversely related to the total grafted thyroid cell number; i.e. more tumors develop per irradiated clonogen in grafts of small cell numbers than of large cell numbers. Recent studies have been ...
ON THE ORIGIN AND MIGRATION OF THE SO‐CALLED PRIMORDIAL GERM CELLS IN THE MOUSE AND THE RAT.1 CS Simkins - 《Acta Zoologica》 被引量: 0发表: 1923年 The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival In mouse embryos, germ cells arise during...
(2007). article cas google scholar sonoda, t., hayashi, c. & kitamura, y. presence of mast cell precursors in the yolk sac of mice. dev. biol. 97 , 89–94 (1983). article cas google scholar gentek, r. et al. hemogenic endothelial fate mapping reveals dual developmental origin of ...
Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin. Cell Dev. Biol. 40, 41–51 (2015). CAS PubMed PubMed Central Google Scholar Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. ...